The effects of pigment epithelium-derived factor on atherosclerosis: putative mechanisms of the process.
The effects of pigment epithelium-derived factor on atherosclerosis: putative mechanisms of the process.
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色素上皮衍生因子对动脉粥样硬化的影响：该过程的假定机制
DOI：
10.1186/s12944-018-0889-z
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发表时间：
2018-10-17
影响因子：
4.5
通讯作者：
Zhu P
中科院分区：
文献类型：
--
作者：
Ma S;Wang S;Li M;Zhang Y;Zhu P
心血管疾病(CVD)是世界范围内主要的死亡原因。动脉粥样硬化被认为是心血管疾病的主要原因，其特征是动脉粥样硬化病变形成和斑块破裂。尽管对动脉粥样硬化机制的认识已经取得了显著的进展，但这些理论在动脉粥样硬化的防治中的应用仍然有限。因此，治疗动脉粥样硬化高危患者的新的有效策略需要进一步开发。色素上皮衍生因子(PEDF)是一种具有抗炎、抗氧化、抗血管生成、抗血栓形成和抗肿瘤作用的糖蛋白，在动脉粥样硬化的预防中具有重要意义。越来越多的研究表明，PEDF对动脉粥样硬化病变和CVD患者具有良好的疗效。我们的团队和同事已经证明PEDF可能与急性冠状动脉综合征(ACS)相关，并且PEDF的rs8075977基因多态与冠状动脉疾病(CAD)相关。此外，我们还探讨了PEDF的抗动脉粥样硬化机制，表明氧化低密度脂蛋白(OX-LDL)通过上调活性氧自由基(ROS)来降低PEDF的浓度，而D-4F则通过抑制PEDF的下调来保护内皮细胞免受OX-LDL诱导的损伤。此外，PEDF可能通过抑制Wnt/β-Catenin途径减轻内皮损伤。这些数据表明，PEDF可能是治疗动脉粥样硬化的新靶点。本文将从内皮功能障碍、炎症反应、氧化应激、血管生成和细胞增殖等方面综述PEDF在动脉粥样硬化形成中的作用。我们还将讨论它对动脉粥样硬化的有前景的治疗意义。
Cardiovascular disease (CVD) is a leading cause of death worldwide. Atherosclerosis is believed to be the major cause of CVD, characterized by atherosclerotic lesion formation and plaque disruption. Although remarkable advances in understanding the mechanisms of atherosclerosis have been made, the application of these theories is still limited in the prevention and treatment of atherosclerosis. Therefore, novel and effective strategies to treat high-risk patients with atherosclerosis require further development. Pigment epithelium-derived factor (PEDF), a glycoprotein with anti-inflammatory, anti-oxidant, anti-angiogenic, anti-thrombotic and anti-tumorigenic properties, is of considerable interest in the prevention of atherosclerosis. Accumulating research has suggested that PEDF exerts beneficial effects on atherosclerotic lesions and CVD patients. Our group, along with colleagues, has demonstrated that PEDF may be associated with acute coronary syndrome (ACS), and that the polymorphisms of rs8075977 of PEDF are correlated with coronary artery disease (CAD). Moreover, we have explored the anti-atherosclerosis mechanisms of PEDF, showing that oxidized-low density lipoprotein (ox-LDL) reduced PEDF concentrations through the upregulation of reactive oxygen species (ROS), and that D-4F can protect endothelial cells against ox-LDL-induced injury by preventing the downregulation of PEDF. Additionally, PEDF might alleviate endothelial injury by inhibiting the Wnt/β-catenin pathway. These data suggest that PEDF may be a novel therapeutic target for the treatment of atherosclerosis. In this review, we will summarize the role of PEDF in the development of atherosclerosis, focusing on endothelial dysfunction, inflammation, oxidative stress, angiogenesis and cell proliferation. We will also discuss its promising therapeutic implications for atherosclerosis.
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DOI：
10.1161/01.atv.0000175759.78338.1e
发表时间：
2005-09-01
影响因子：
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作者：
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影响因子：
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DOI：
10.1097/00005072-199907000-00006
发表时间：
1999-07-01
影响因子：
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