RATES OF NUCLEOTIDE SUBSTITUTION VARY GREATLY AMONG PLANT MITOCHONDRIAL, CHLOROPLAST, AND NUCLEAR DNAS
RATES OF NUCLEOTIDE SUBSTITUTION VARY GREATLY AMONG PLANT MITOCHONDRIAL, CHLOROPLAST, AND NUCLEAR DNAS
复制标题
DOI：
10.1073/pnas.84.24.9054
复制
发表时间：
1987-12-01
影响因子：
11.1
通讯作者：
SHARP, PM
中科院分区：
文献类型：
--
作者：
WOLFE, KH;LI, WH;SHARP, PM
植物线粒体（mt）、叶绿体（cp）和细胞核(n) DNA序列的比较表明，mtDNA的沉默替代率不到cpDNA的三分之一，而cpDNA的进化速度只有植物nDNA的一半。mtDNA的速率比cpDNA慢可能是由于较低的突变率。植物和哺乳动物mtdna的沉默替代率相差一到两个数量级，而nDNAs的沉默替代率可能相似。在cpDNA中，与单拷贝序列相比，倒置重复序列中同义位点和非编码序列的替代率大大降低。在单子叶/双子叶分裂后，cpDNA的进化速度在一些双子叶谱系中似乎有所减缓，并且在非同义位点比同义位点的减缓更为明显。
Comparison of plant mitochondrial (mt), chloroplast (cp) and nuclear (n) DNA seuquences shows that the silent substitution rate in mtDNA is less than one-third that in cpDNA, which in turn evolves only half as fast as plant nDNA. The slower rate in mtDNA than in cpDNA is probably due to a lower mutation rate. Silent substitution rates in plant and mammalian mtDNAs differ by one or two orders of magnitude, whereas the rates in nDNAs may be similar. In cpDNA, the rate of substitution both at synonymous sites and in noncoding sequences in the inverted repeat is greatly reduced in comparison to single-copy sequences. The rate of cpDNA evolution appears to have slowed in some dicot lineages following the monocot/dicot split, and the slowdown is more conspicuous at nonsynonymous sites than at synonymous sites.