Relationship between morphological changes and endotoxin release induced by carbapenems in Pseudomonas aeruginosa
Relationship between morphological changes and endotoxin release induced by carbapenems in Pseudomonas aeruginosa
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DOI：
10.1099/00222615-48-3-309
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发表时间：
1999-03-01
影响因子：
3
通讯作者：
Kobayashi, M
中科院分区：
文献类型：
--
作者：
Horii, T;Ichiyama, S;Kobayashi, M
The relationship between morphological changes and endotoxin release induced in vitro by carbapenems in a clinical isolate of Pseudomonas aeruginosa was examined. The time-course and magnitude of endotoxin release induced varied among imipenem, panipenem, meropenem and biapenem and related to the morphological changes caused by these agents which variously affected cell shape, cell-wall disintegration and cell lysis, The amount of endotoxin released by carbapenem-treated cells correlated with both the cell-wall morphology and bacterial shape immediately before lysis, Meropenem and biapenem caused markedly increased endotoxin release during cell lysis and cell-wall disintegration, whereas imipenem and panipenem caused much less release of endotoxin.
