Replication of alphaviruses: a review on the entry process of alphaviruses into cells.
Replication of alphaviruses: a review on the entry process of alphaviruses into cells.
复制标题
DOI：
10.1155/2011/249640
复制
发表时间：
2011
影响因子：
2.2
通讯作者：
Chu JJ
中科院分区：
文献类型：
--
作者：
Leung JY;Ng MM;Chu JJ
甲病毒是一种小型包膜病毒，直径约70 nm，含有单链正义RNA基因组。属于该属的病毒主要是节肢动物传播的病毒，已知会引起人类疾病。它们对人类健康的潜在威胁最近的例子是2005年在留尼汪岛爆发的基孔肯雅病毒，这突出表明有必要了解这些医学上重要的人类病原体生命周期中的事件。病毒的复制和繁殖依赖于进入允许细胞。病毒进入是通过病毒体附着到细胞上开始的，导致内化，并脱壳以释放用于复制和繁殖的遗传物质。对甲病毒的研究揭示了通过受体介导的内吞途径进入。本文以塞姆利基森林病毒、辛德毕斯病毒、基孔肯雅病毒和委内瑞拉马脑炎病毒为例，对甲病毒进入的不同阶段进行了研究。
Alphaviruses are small, enveloped viruses, ~70 nm in diameter, containing a single-stranded, positive-sense, RNA genome. Viruses belonging to this genus are predominantly arthropod-borne viruses, known to cause disease in humans. Their potential threat to human health was most recently exemplified by the 2005 Chikungunya virus outbreak in La Reunion, highlighting the necessity to understand events in the life-cycle of these medically important human pathogens. The replication and propagation of viruses is dependent on entry into permissive cells. Viral entry is initiated by attachment of virions to cells, leading to internalization, and uncoating to release genetic material for replication and propagation. Studies on alphaviruses have revealed entry via a receptor-mediated, endocytic pathway. In this paper, the different stages of alphavirus entry are examined, with examples from Semliki Forest virus, Sindbis virus, Chikungunya virus, and Venezuelan equine encephalitis virus described.