Factors associated with prospective long-term treatment adherence among individuals with bipolar disorder
Factors associated with prospective long-term treatment adherence among individuals with bipolar disorder
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DOI：
10.1176/appi.ps.59.7.753
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发表时间：
2008-07-01
影响因子：
3.8
通讯作者：
Bauer, Mark S.
中科院分区：
文献类型：
--
作者：
Sajatovic, Martha;Biswas, Kousick;Bauer, Mark S.
目的：在横断面研究中，临床特征、药物不良反应和治疗态度与双相情感障碍人群的依从性相关。这项来自大型研究的次要分析的目的是确定基线变量与随后三年内平均治疗依从性之间的关联。方法：在基线和三年内每六个月对患有双相情感障碍的退伍军人自我报告的依从性状态进行评估。样本被分为两个临床相关类别：那些谁主要是粘附和那些谁主要是非粘附。人口统计学和临床变量进行了检查，两组患者的平均依从性在三年内。结果：该研究招募了306名严重双相情感障碍患者。样本主要为男性（278名男性，或91%），平均+/- SD年龄为46.6 +/- 10.1岁。共有240人（78%）基本上坚持治疗，37人（12%）基本上不坚持治疗。非依从性个体不太可能接受强化体细胞治疗方案（p=. 001）;经历了更多的护理障碍，包括缺乏电话接入（p
Objective: Clinical characteristics, adverse effects of medication, and treatment attitudes have been associated with adherence in bipolar populations in cross-sectional studies. The aim of this secondary analysis from a larger study was to identify the association between baseline variables and average treatment adherence over a subsequent three-year period. Methods: Veterans with bipolar disorder were evaluated on self-reported adherence status at baseline and every six months over a three-year period. The sample was dichotomized into two clinically relevant categories: those who were primarily adherent and those who were primarily nonadherent. Demographic and clinical variables were examined for the two groups of patients in relation to their average adherence over the three-year period. Results: The study recruited a sample of 306 persons with severe bipolar disorder. The sample was predominantly male ( 278 men, or 91%), with a mean +/- SD age of 46.6 +/- 10.1 years. A total of 240 individuals ( 78%) were largely adherent to treatment, and 37 individuals ( 12%) were largely nonadherent to treatment. Nonadherent individuals were less likely to be on intensive somatotherapy regimens ( p=. 001); experienced more barriers to care, including lack of telephone access ( p