Modulation of social space by dopamine in Drosophila melanogaster, but no effect on the avoidance of the Drosophila stress odorant
Modulation of social space by dopamine in Drosophila melanogaster, but no effect on the avoidance of the Drosophila stress odorant
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DOI：
10.1098/rsbl.2017.0369
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发表时间：
2017-08-01
期刊：
影响因子：
3.3
通讯作者：
Simon, Anne F.
中科院分区：
文献类型：
--
作者：
Fernandez, Robert W.;Akinleye, Adesanya A.;Simon, Anne F.
对他人作出适当的反应是社会交往的必要条件。然而，人们对神经递质如何调节有吸引力和令人反感的社会暗示知之甚少。通过对黑腹果蝇的遗传和药理学操作，我们发现多巴胺有助于对社会群体中其他个体的反应，特别是社会间隔，而不是避免压力苍蝇（dSO）释放的气味。有趣的是，这种多巴胺介导的行为只在白天突出，其影响取决于组织、性别和操作类型。此外，多巴胺水平的改变对dSO回避没有影响，这表明一种不同的神经递质调节这种反应。
Appropriate response to others is necessary for social interactions. Yet little is known about how neurotransmitters regulate attractive and repulsive social cues. Using genetic and pharmacological manipulations in Drosophila melanogaster, we show that dopamine is contributing the response to others in a social group, specifically, social spacing, but not the avoidance of odours released by stressed flies (dSO). Interestingly, this dopamine-mediated behaviour is prominent only in the day-time, and its effect varies depending on tissue, sex and type of manipulation. Furthermore, alteration of dopamine levels has no effect on dSO avoidance regardless of sex, which suggests that a different neurotransmitter regulates this response.