The potential of auto-antigen-guided treatment of immune checkpoint inhibitor-mediated myocarditis.
The potential of auto-antigen-guided treatment of immune checkpoint inhibitor-mediated myocarditis.
复制标题
自身抗原引导治疗免疫检查点抑制剂介导的心肌炎的潜力。
DOI：
10.1016/j.medj.2022.12.005
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Wu,SeanM
中科院分区：
文献类型：
--
作者：
Zhu,Han;Huang,YuhsinVivian;Wu,SeanM
免疫检查点抑制剂 (ICI) 介导的心肌炎是癌症免疫治疗的一种罕见但具有破坏性的副作用，受影响患者的死亡率高达 40%，并会出现心律失常和心力衰竭等长期心脏问题。1最近，Axelrod 等人2建议将自身抗原驱动机制作为这种疾病的免疫学基础。
Immune checkpoint inhibitor (ICI)-mediated myocarditis is a rare but devastating side effect of cancer immunotherapy with up to 40% mortality and long-term cardiac issues such as arrhythmias and heart failure in affected patients.1Recently, Axelrod et al.2suggested an auto-antigen-driven mechanism as the immunological basis for this disease.