D-Serine rescues the deficits of hippocampal long-term potentiation and learning and memory induced by sodium fluoroacetate
D-Serine rescues the deficits of hippocampal long-term potentiation and learning and memory induced by sodium fluoroacetate
复制标题
d-丝氨酸挽救氟乙酸钠引起的海马长时程增强和学习记忆缺陷
DOI：
10.1016/j.pbb.2015.03.017
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发表时间：
2015-06-01
影响因子：
3.6
通讯作者：
Dong, Zhifang
中科院分区：
文献类型：
--
作者：
Han, Huili;Peng, Yan;Dong, Zhifang
胶质细胞-神经元双向相互作用在神经生理和病理过程中起着重要作用。研究发现氟乙酸钠（FAC）损伤神经胶质细胞功能可导致海马长时程抑制（LTD）和空间记忆提取障碍。然而，它仍然是未知的，是否FAC损害海马长时程增强（LTP）和学习和/或记忆，如果是这样的话，是否与外源性D-丝氨酸的药物治疗可以回避损害。在此，我们报道了全身施用FAC（3 mg/kg，i. p.）在水迷宫中的空间学习记忆和情境恐惧条件下的恐惧记忆均显著受损。此外，行为缺陷伴随着脑片海马CA 1区LTP诱导受损。更重要的是，外源性o-丝氨酸治疗成功地消除了FAC引起的海马LTP和学习记忆障碍。总之，这些结果表明，星形胶质细胞D-丝氨酸可能是必不可少的海马突触可塑性和记忆，其水平的改变可能与诱导和潜在的治疗精神和神经系统疾病。(C)2015 Elsevier Inc. All rights reserved.
It is well known that bidirectional glia-neuron interactions play important roles in the neurophysiological and neuropathological processes. It is reported that impairing glial functions with sodium fluoroacetate (FAC) impaired hippocampal long-term depression (LTD) and spatial memory retrieval. However, it remains unknown whether FAC impairs hippocampal long-term potentiation (LTP) and learning and/or memory, and if so, whether pharmacological treatment with exogenous D-serine can recuse the impairment. Here, we reported that systemic administration of FAC (3 mg/kg, i.p.) before training resulted in dramatic impairments of spatial learning and memory in water maze and fear memory in contextual fear conditioning. Furthermore, the behavioral deficits were accompanied by impaired LTP induction in the hippocampal CA1 area of brain slices. More importantly, exogenous o-serine treatment succeeded in recusing the deficits of hippocampal LTP and learning and memory induced by FAC. Together, these results suggest that astrocytic D-serine may be essential for hippocampal synaptic plasticity and memory, and that alteration of its levels may be relevant to the induction and potentially treatment of psychiatric and neurological disorders. (C) 2015 Elsevier Inc. All rights reserved.