The role of molecular microtubule motors and the microtubule cytoskeleton in stress granule dynamics.
The role of molecular microtubule motors and the microtubule cytoskeleton in stress granule dynamics.
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DOI：
10.1155/2011/939848
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发表时间：
2011
影响因子：
--
通讯作者：
Saunders WS
中科院分区：
文献类型：
--
作者：
Bartoli KM;Bishop DL;Saunders WS
应激颗粒（SGs）是暴露于应激诱导的翻译抑制的细胞中出现的细胞质病灶。SGs作为一个分类中心，在那里mRNA被分类储存，降解和翻译重新启动。虽然已经确定了许多关键参与者，但SGs动态的基本机制仍在描述中。SGs的主要成分是停滞的48S前起始复合物。迄今为止，还发现许多其他蛋白质定位于SG中，并假设在SG动力学中发挥作用。最近，微管细胞骨架和相关的马达蛋白已被证明在SG动力学中起作用。在本文中，我们将讨论目前的文献研究的功能，微管和分子微管马达SG组装，聚结，运动，组成，组织和拆卸。
Stress granules (SGs) are cytoplasmic foci that appear in cells exposed to stress-induced translational inhibition. SGs function as a triage center, where mRNAs are sorted for storage, degradation, and translation reinitiation. The underlying mechanisms of SGs dynamics are still being characterized, although many key players have been identified. The main components of SGs are stalled 48S preinitiation complexes. To date, many other proteins have also been found to localize in SGs and are hypothesized to function in SG dynamics. Most recently, the microtubule cytoskeleton and associated motor proteins have been demonstrated to function in SG dynamics. In this paper, we will discuss current literature examining the function of microtubules and the molecular microtubule motors in SG assembly, coalescence, movement, composition, organization, and disassembly.