Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)
Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)
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台中宁 A-D，来自台中曲霉的去甲萜 (IBT 19404)
DOI：
10.1021/acs.jnatprod.8b01032
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发表时间：
2019
影响因子：
5.1
通讯作者：
Tsukamoto Sachiko
中科院分区：
文献类型：
--
作者：
Kato Hikaru;Sebe Momona;Nagaki Mika;Eguchi Keisuke;Kagiyama Ippei;Hitora Yuki;Frisvad Jens C.;Williams Robert M.;Tsukamoto Sachiko
从台湾曲霉（IBT 19404）中分离到4个新的北二萜，分别为taichunins A-D（1-4）。化合物1有一个新的碳骨架。用计算ECD谱法确定了绝对构型。化合物1对HeLa细胞具有细胞毒性，ic50值为4.5 μM，而化合物2 - 4在50 μM时无毒性。
Four new norditerpenes, taichunins A–D (1–4), were isolated from the fungusAspergillus taichungensis(IBT 19404). Compound1has a new carbon framework. The absolute configurations were determined by the calculated ECD spectral method. Compound1was cytotoxic against HeLa cells with an IC50value of 4.5 μM, whereas2–4were nontoxic at 50 μM.