From bench to bedside a comprehensive review of pancreatic cancer immunotherapy.
From bench to bedside a comprehensive review of pancreatic cancer immunotherapy.
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从长凳到床边，对胰腺癌免疫疗法进行了全面评论。
DOI：
10.1186/s40425-016-0119-z
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发表时间：
2016
影响因子：
10.9
通讯作者：
Rahma OE
中科院分区：
文献类型：
--
作者：
Kunk PR;Bauer TW;Slingluff CL;Rahma OE
胰腺癌的发病率一直在上升，但其5年生存率几十年来没有变化。在个性化医疗的时代，免疫疗法已经成为一种有希望的治疗多种恶性肿瘤的方式，包括胰腺癌。本综述将讨论独特的胰腺肿瘤微环境，包括将胰腺从正常结构转变为抑制免疫细胞和致密细胞外基质的复杂混合物的细胞和受体，从而允许癌细胞不受限制地生长。接下来，我们将重点介绍最近完成的胰腺癌免疫治疗临床试验。最后，我们将探讨正在进行的免疫治疗临床试验和未来的方向，这一引人入胜和不断变化的领域。
The incidence of pancreatic cancer has been increasing while its 5-year survival rate has not changed in decades. In the era of personalized medicine, immunotherapy has emerged as a promising treatment modality in a variety of malignancies, including pancreatic cancer. This review will discuss the unique pancreatic tumor microenvironment, including the cells and receptors that transform the pancreas from its normal architecture into a complex mix of suppressor immune cells and dense extracellular matrix that allows for the unrestricted growth of cancer cells. Next, we will highlight the recently completed immunotherapy clinical trials in pancreatic cancer. Finally, we will explore the on-going immunotherapy clinical trials and future directions of this engaging and changing field.