Functional networking of human divergently paired genes (DPGs).
Functional networking of human divergently paired genes (DPGs).
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DOI：
10.1371/journal.pone.0078896
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Lei H
中科院分区：
文献类型：
--
作者：
Xie B;Wang D;Duan Y;Yu J;Lei H
Divergently paired genes (DPGs), also known as bidirectional (head-to-head positioned) genes, are conserved across species and lineages, and thus deemed to be exceptional in genomic organization and functional regulation. Despite previous investigations on the features of their conservation and gene organization, the functional relationship among DPGs in a given species and lineage has not been thoroughly clarified. Here we report a network-based comprehensive analysis on human DPGs and our results indicate that the two members of the DPGs tend to participate in different biological processes while enforcing related functions as modules. Comparing to randomly paired genes as a control, the DPG pairs have a tendency to be clustered in similar “cellular components” and involved in similar “molecular functions”. The functional network bridged by DPGs consists of three major modules. The largest module includes many house-keeping genes involved in core cellular activities. This module also shows low variation in expression in both CNS (central nervous system) and non-CNS tissues. Based on analyses of disease transcriptome data, we further suggest that this particular module may play crucial roles in HIV infection and its disease mechanism.
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影响因子：
14.9
作者：
Kanehisa M;Goto S;Sato Y;Furumichi M;Tanabe M
通讯作者：
Tanabe M
DOI：
10.1086/605446
发表时间：
2009-09-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Pereyra F;Palmer S;Miura T;Block BL;Wiegand A;Rothchild AC;Baker B;Rosenberg R;Cutrell E;Seaman MS;Coffin JM;Walker BD
通讯作者：
Walker BD
DOI：
10.1084/jem.20070784
发表时间：
2007-10-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Almeida JR;Price DA;Papagno L;Arkoub ZA;Sauce D;Bornstein E;Asher TE;Samri A;Schnuriger A;Theodorou I;Costagliola D;Rouzioux C;Agut H;Marcelin AG;Douek D;Autran B;Appay V
通讯作者：
Appay V
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
7
作者：
Lin, Jane M.;Collins, Patrick J.;Weng, Zhiping
通讯作者：
Weng, Zhiping