Insights into household transmission of SARS-CoV-2 from a population-based serological survey.
Insights into household transmission of SARS-CoV-2 from a population-based serological survey.
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DOI：
10.1038/s41467-021-23733-5
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发表时间：
2021-06-15
影响因子：
16.6
通讯作者：
SEROCoV-POP Study Group
中科院分区：
文献类型：
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作者：
Bi Q;Lessler J;Eckerle I;Lauer SA;Kaiser L;Vuilleumier N;Cummings DAT;Flahault A;Petrovic D;Guessous I;Stringhini S;Azman AS;SEROCoV-POP Study Group
了解家庭和社区接触造成的感染风险以及无症状感染的传播性对于控制 SARS-CoV-2 至关重要。先前有限的证据主要基于病毒学检测，这种检测不成比例地漏掉了轻度和无症状感染。血清学措施更有可能捕获所有先前感染的个体。我们将家庭传播模型应用于一项横断面、以家庭为基础的人口血清调查数据，该调查对 2020 年 4 月至 6 月在瑞士日内瓦登记的 2,267 个家庭中的 4,534 名年龄≥5 岁的人进行了调查。我们发现，在第一波大流行期间，暴露于一名年龄≥5岁的受感染家庭成员的感染风险（17.3%，13.7-21.7）是家庭外暴露的三倍多（5.1%，4.5-5.8）。幼儿被家庭成员感染的风险较低。工作年龄的成年人的家庭外感染风险最高。与报告有症状的家庭成员相比，血清反应呈阳性的无症状家庭成员感染其他家庭成员的几率低 69.4%（95%CrI，31.8-88.8%），占所有家庭感染的 14.5%（95%CrI，7.2-22.7%）。以家庭为基础的研究可以深入了解 SARS-CoV-2 的传播。在这里，作者将传播模型与瑞士日内瓦的血清学数据进行了拟合，并估计单个家庭暴露的感染风险 (17.3%) 高于家庭外暴露的感染风险 (5.1%)。
Understanding the risk of infection from household- and community-exposures and the transmissibility of asymptomatic infections is critical to SARS-CoV-2 control. Limited previous evidence is based primarily on virologic testing, which disproportionately misses mild and asymptomatic infections. Serologic measures are more likely to capture all previously infected individuals. We apply household transmission models to data from a cross-sectional, household-based population serosurvey of 4,534 people ≥5 years from 2,267 households enrolled April-June 2020 in Geneva, Switzerland. We found that the risk of infection from exposure to a single infected household member aged ≥5 years (17.3%,13.7-21.7) was more than three-times that of extra-household exposures over the first pandemic wave (5.1%,4.5-5.8). Young children had a lower risk of infection from household members. Working-age adults had the highest extra-household infection risk. Seropositive asymptomatic household members had 69.4% lower odds (95%CrI,31.8-88.8%) of infecting another household member compared to those reporting symptoms, accounting for 14.5% (95%CrI, 7.2-22.7%) of all household infections. Household-based studies can provide insights into SARS-CoV-2 transmission. Here, the authors fit transmission models to serological data from Geneva, Switzerland, and estimate that the risk of infection from single household exposure (17.3%) was higher than for extra-household exposure (5.1%).