Vulnerability to insomnia: the role of familial aggregation.
Vulnerability to insomnia: the role of familial aggregation.
复制标题
容易失眠：家族聚集的作用。
DOI：
10.1016/j.sleep.2007.04.012
复制
发表时间：
2008
期刊：
影响因子：
4.8
通讯作者：
Roth,Thomas
中科院分区：
文献类型：
--
作者：
Drake,ChristopherL;Scofield,Holly;Roth,Thomas
BACKGROUNDThe goal of this study was to determine the degree of familial aggregation in vulnerability to stress-related sleep disturbance among siblings. One approach to investigating a potential “familial” predisposition to sleep disturbance is to examine the relationship between siblings on a standard measure of vulnerability to stress-related sleep disturbance.DESIGNCross-sectional data on insomnia, vulnerability to stress-related sleep disturbance, sleepiness, habitual sleep, and additional demographic variables was collected separately from pairs of biological siblings. Data were collected during a 15–20min phone assessment.PARTICIPANTSInterviews on a total of 62 individuals (31 sibling pairs) were completed. A total of 8 individuals and their respective siblings were excluded after meeting conservative criteria for Diagnostic and Statistical Manual of Mental Disorders, Fourth edition (DSM-IV)-based insomnia. The mean age of the sample was 51.1±12.1 years (range 18–70) and habitual nightly total sleep time averaged 6.91±1.42h/night.RESULTSIndividuals completed the Ford Insomnia Response to Stress Test (FIRST), a standardized measure of individual vulnerability to stress-induced sleep disturbance. The intraclass correlation coefficient (ICC) was r =0.61, df=23, p =0.001 for the relationship between siblings in FIRST scores. This indicated that 37.2% of the variance in vulnerability to stress-related sleep disturbance can be accounted for by familial aggregation. This relationship remained after controlling for potential confounds including age, gender, shift schedule, and psychiatric history.CONCLUSIONSOur data support the notion that vulnerability to stress-related sleep disturbance has a strong familial aggregation. Additional studies are needed to determine the genetic or environmental origins of this relationship and its underlying biological substrates.
