Diagnosis and management of HIV drug hypersensitivity
Diagnosis and management of HIV drug hypersensitivity
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DOI：
10.1016/j.jaci.2007.10.021
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发表时间：
2008-04-01
影响因子：
14.2
通讯作者：
Shearer, William T.
中科院分区：
文献类型：
--
作者：
Davis, Carla M.;Shearer, William T.
药物超敏反应是服用复杂药物方案的HIV感染患者发病的重要原因。这些反应的正确诊断和管理在HIV疾病的临床护理中至关重要。甲氧苄啶-磺胺甲恶唑、阿巴卡韦、奈韦拉平、阿扎那韦和恩夫韦肽都可引起过敏性皮疹。在这篇综述中，我们讨论了对HIV药物过敏反应的免疫学机制的证据，这些反应的临床特征，以及目前存在的识别和管理指南。
Drug hypersensitivity reactions are an important cause of morbidity in HIV-infected patients who take complex medication regimens. Correct diagnosis and management of these reactions are essential in the clinical care of HIV disease. Trimethoprim-sulfamethoxazole, abacavir, nevirapine, atazanavir, and enfuvirtide can all cause hypersensitivity rashes. In this review, we discuss the evidence for immunologic mechanisms of hypersensitivity reactions to HIV medications, the clinical characteristics of these reactions, and guidelines that currently exist for their identification and management.