INPUT FROM THE AMYGDALA TO THE RAT NUCLEUS-ACCUMBENS - ITS RELATIONSHIP WITH TYROSINE-HYDROXYLASE IMMUNOREACTIVITY AND IDENTIFIED NEURONS
INPUT FROM THE AMYGDALA TO THE RAT NUCLEUS-ACCUMBENS - ITS RELATIONSHIP WITH TYROSINE-HYDROXYLASE IMMUNOREACTIVITY AND IDENTIFIED NEURONS
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DOI：
10.1016/0306-4522(94)90408-1
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发表时间：
1994-08-01
期刊：
影响因子：
3.3
通讯作者：
TOTTERDELL, S
中科院分区：
文献类型：
--
作者：
JOHNSON, LR;AYLWARD, RLM;TOTTERDELL, S
来自中边缘多巴胺系统的酪氨酸羟酶阳性纤维和来自基底外侧核的杏仁核投射纤维都主要终止于伏隔核。尾侧杏仁核纤维沿背向通过终纹密集地投射到伏隔核壳，特别是在富含多巴胺的隔钩。杏仁核与情感相关刺激的识别有关，而中脑边缘多巴胺系统与奖励机制有关。行为学和电生理学证据表明，杏仁核对伏隔核的输入受到中脑边缘多巴胺输入的调节，但尚不清楚这些途径在伏隔核内的解剖作用。利用各种神经解剖学技术，包括顺行和逆行示踪、免疫细胞化学和细胞内填充，我们已经证明了这些输入在中等棘神经元上的收敛性。基底外侧杏仁核投射的末端主要在脊柱的头部形成不对称的突触，这些突触也在颈部或邻近的树突上接收来自中边缘多巴胺系统的对称突触输入。这些神经元中的一些也被确定为投射神经元，可能到腹侧苍白球。我们已经在突触水平上展示了多巴胺是如何调节伏隔核兴奋性边缘输入的。
Both tyrosine hydroxylase-positive fibres from the mesolimbic dopamine system and amygdala projection fibres from the basolateral nucleus are known to terminate heavily in the nucleus accumbens. Caudal amygdala fibres travelling dorsally via the stria terminalis project densely to the nucleus accumbens shell, especially in the dopamine rich septal hook. The amygdala has been associated with the recognition of emotionally relevant stimuli while the mesolimbic dopamine system is implicated with reward mechanisms. There is behavioural and electrophysiological evidence that the amygdala input to the nucleus accumbens is modulated by the mesolimbic dopamine input, but it is not known how these pathways interact anatomically within the nucleus accumbens. Using a Variety of neuroanatomical techniques including anterograde and retrograde tracing, immunocytochemistry and intracellular filling, we have demonstrated convergence of these inputs on to medium-sized spiny neurons. The terminals of the basolateral amygdala projection make asymmetrical synapses predominantly on the heads of spines which also receive on their necks or adjacent dendrites, symmetrical synaptic input from the mesolimbic dopamine system. Some of these neurons have also been identified as projection neurons, possibly to the ventral pallidum.We have shown a synaptic level how dopamine is positioned to modulate excitatory limbic input in the nucleus accumbens.