Prenatal chromium exposure and risk of preterm birth: a cohort study in Hubei, China.
Prenatal chromium exposure and risk of preterm birth: a cohort study in Hubei, China.
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产前铬暴露与早产风险：中国湖北省的一项队列研究
DOI：
10.1038/s41598-017-03106-z
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发表时间：
2017-06-08
影响因子：
4.6
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Pan X;Hu J;Xia W;Zhang B;Liu W;Zhang C;Yang J;Hu C;Zhou A;Chen Z;Cao J;Zhang Y;Wang Y;Huang Z;Lv B;Song R;Zhang J;Xu S;Li Y
在普通人群中，很少有研究调查环境铬暴露与早产之间的关联。本研究旨在利用2012年至2014年在中国湖北进行的健康婴儿队列研究（n = 7290）的数据，调查孕期母亲铬暴露是否与孕周减少或早产风险相关。采用电感耦合等离子体质谱法测定分娩时收集的母亲尿液样本中的铬浓度。在多变量线性回归分析中，铬浓度的三分位数与孕周呈负相关[β（95%置信区间）：低 = 参照组；中 = -0.67天（-1.14，-0.20）；高 = -2.30天（-2.93，-1.67）；趋势p <0.01]。逻辑回归分析还表明，母亲体内铬含量较高[调整后的比值比（OR）（95%置信区间）：中三分位数为1.55（0.99，2.42）；高三分位数为1.89（1.13，3.18）；趋势p <0.01]与早产风险增加相关。这种关联在男婴中似乎更为明显[调整后的OR（95%置信区间）：中三分位数为2.54（1.29，4.95）；高三分位数为2.92（1.37，6.19）；趋势p <0.01]。我们的研究结果表明，孕期母亲暴露于较高水平的铬可能会潜在地增加早产的风险，尤其是男婴。
Few studies have investigated the association of environmental chromium exposure and preterm birth in general population. This study was designed to investigate whether maternal chromium exposure during pregnancy is associated with reduced gestational age or risk of preterm birth using the data from Healthy Baby Cohort study conducted in Hubei, China between 2012 and 2014 (n = 7290). Chromium concentrations in maternal urine samples collected at delivery were measured with inductively coupled plasma mass spectrometry. Tertiles of chromium concentrations was negatively associated with gestational age in multivariable linear regression analyses [β (95% CI): low = reference; middle = −0.67 days (−1.14, −0.20); high = −2.30 days (−2.93, −1.67);ptrend <0.01]. Logistic regression analyses also indicated that higher maternal chromium [adjusted odds ratio (OR) (95% CI): 1.55(0.99, 2.42) for the medium tertile; 1.89(1.13, 3.18) for the highest tertile;ptrend <0.01] was associated with increased risk of preterm birth. The associations appeared to be more pronounced in male infants (adjusted OR (95% CI): 2.54 (1.29, 4.95) for the medium tertile; 2.92 (1.37, 6.19) for the highest tertile;ptrend <0.01). Our findings suggest maternal exposure to higher chromium levels during pregnancy may potentially increase the risk of delivering preterm infants, particularly for male infants.