Quantification of age-related changes in the structure model type and trabecular thickness of human tibial cancellous bone
Quantification of age-related changes in the structure model type and trabecular thickness of human tibial cancellous bone
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DOI：
10.1016/s8756-3282(99)00281-1
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发表时间：
2000-03-01
期刊：
影响因子：
4.1
通讯作者：
Hvid, I
中科院分区：
文献类型：
--
作者：
Ding, M;Hvid, I
结构模型类型和骨小梁厚度是描述松质骨结构的重要特征。已经定性地观察到骨小梁从板状到杆状的根本变化发生在衰老、骨重建和骨质疏松症中。骨小梁的厚度传统上使用基于模型的组织形态学方法在二维（2-D）切片上测量。然而，没有定量研究已发表的基础上，三维（3-D）的方法对年龄相关的变化，结构模型类型和骨小梁厚度的人外周（胫骨）松质骨。在这项研究中，160人胫骨近端松质骨标本从40名正常人，年龄16至85岁，收集。这些标本进行显微计算机断层扫描（micro-CT），然后micro-CT图像分割使用最佳阈值。采用新的三维测量方法对前向精确三维数据集、结构模型类型和骨小梁厚度进行量化，通过计算结构模型指数（SMI）来评估结构模型类型。SMI基于结构的三角形骨表面的差异分析来量化。该技术允许量化结构模型类型，例如板、杆对象或板或杆的混合物。骨小梁厚度直接从3D图像计算，这对于先验未知或变化的结构尤其重要。结果表明，老年人骨小梁结构类型向杆型转变，骨小梁厚度随年龄增长而明显下降。这些变化在80岁后变得显著，而这两个属性似乎在20至80岁之间保持相对不变。虽然三维骨小梁厚度与二维骨小梁厚度之间存在相当密切的关系，但二维方法明显低估了真实的三维骨小梁厚度。(C)2000年由爱思唯尔科学公司，里尔保留权利。
Structure model type and trabecular thickness are important characteristics in describing cancellous bone architecture. It has been qualitatively observed that a radical change of trabeculae from plate-like to rod-like occurs in aging, bone remodeling, and osteoporosis. Thickness of trabeculae has traditionally been measured using model-based histomorphometric methods on two-dimensional (2-D) sections. However, no quantitative study has been published based on three-dimensional (3-D) methods on the age-related changes in structure model type and trabecular thickness for human peripheral (tibial) cancellous bone. In this study, 160 human proximal tibial cancellous bone specimens from 40 normal donors, aged 16 to 85 years, were collected. These specimens were micro-computed tomography (micro-CT) scanned, then the micro-CT images were segmented using optimal thresholds. Front accurate 3-D data sets, structure model type and trabecular thickness were quantified by means of novel 3-D methods, Structure model type was assessed by calculating the structure model index (SMI). The SMI mas quantified based on a differential analysis of the triangulated bone surface of a structure. This technique allows quantification of structure model type, such as plate, rod objects, or mixture of plates or rods, Trabecular thickness is calculated directly from 3-D images, which is especially important for an a priori unknown or changing structure. Furthermore, 2-D trabecular thickness was also calculated based on the plate model, Our results showed that structure model type changed towards more rod-like in the elderly, and that trabecular thickness declined significantly with age. These changes become significant after 80 years of age for human tibial cancellous bone, whereas both properties seem to remain relatively unchanged between 20 and 80 years. Although a fairly close relationship was seen between 3-D trabecular thickness and 2-D trabecular thickness, real 3-D trabecular thickness was significantly underestimated using 2-D method. (C) 2000 by Elsevier Science Inc, rill rights reserved.