Emerging Therapies for Intestinal Failure
Emerging Therapies for Intestinal Failure
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DOI：
10.1001/archsurg.2010.102
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发表时间：
2010-06-01
影响因子：
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通讯作者：
Tappenden, Kelly A.
中科院分区：
文献类型：
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作者：
Tappenden, Kelly A.
鉴于不可估量的人类痛苦和医疗保健负担与肠道衰竭，医学治疗，旨在肠道康复是必要的。在大量小肠切除术后，已知残留的肠在结构和功能上适应，以试图补偿切除的部分。然而，肠外营养可能与许多短期和长期并发症有关，包括由于缺乏口服或肠内营养提供的刺激而导致的肠道适应性障碍和促进粘膜萎缩。然而，本文的数据表明，丁酸盐（一种通过膳食纤维发酵在结肠中产生的短链脂肪酸）的添加在添加到胃肠外营养中时刺激肠适应，这表明可以配制当前的溶液以优化肠适应并减少接受长期胃肠外营养方案的肠衰竭个体的依赖性。《外科学》2010;145（6）：528-532
Given the immeasurable human distress and -health care burden associated with intestinal failure, medical therapies aimed at intestinal rehabilitation are needed. Following massive small-bowel resection, the residual intestine is known to adapt structurally and functionally in an attempt to compensate for the resected portion. However, parenteral nutrition may be associated with many short- and long-term complications, including prevention of intestinal adaptation and promotion of mucosal atrophy due to lack of stimulus provided by oral or enteral nutrition. However, data herein demonstrate that the addition of butyrate, a short-chain fatty acid produced in the colon by dietary fiber fermentation, stimulates intestinal adaptation when added to parenteral nutrition, indicating that current solutions could be formulated to optimize intestinal adaptation and to reduce dependence of individuals with intestinal failure receiving long-term parenteral nutrition regimens. Arch Surg. 2010;145(6):528-532