Altered angiotensin II sensitivity of neurons in the organum vasculosum lamina terminalis region of the spontaneously hypertensive rat.
Altered angiotensin II sensitivity of neurons in the organum vasculosum lamina terminalis region of the spontaneously hypertensive rat.
复制标题
改变自发性高血压大鼠血管器终板区域神经元的血管紧张素 II 敏感性。
DOI：
10.1016/0006-8993(88)90911-0
复制
发表时间：
1988
期刊：
影响因子：
2.9
通讯作者：
Nelson,DO
中科院分区：
文献类型：
--
作者：
Nelson,DO
采用离体下丘脑脑切片，比较了自发性高血压大鼠（SHR）和年龄匹配的正常血压Wistar-Kyoto大鼠（WKY）血管终板（OVLT）区神经元血管紧张素II （AII）敏感性的差异。在所有的竞争拮抗剂saralasin和l-谷氨酸微压作用于OVLT神经元。同时应用saralasin可阻断或拮抗SHR神经元的AII兴奋，与WKY对照制剂中的OVLT神经元相比，SHR神经元的激活阈值显著降低，且后活性期延长。神经元对谷氨酸的反应在两个大鼠品系之间相似。神经元对AII的敏感性差异可能与SHR患者的高血压有因果关系。
Using in vitro hypothalamic brain slices, differences in angiotensin II (AII) sensitivity of neurons in the organum vasculosum lamina terminalis (OVLT) region were compared between spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar-Kyoto rats (WKY). AIIm the AII competitive antagonist saralasin, andl-glutamate were micropressure-applied onto OVLT neurons. AII excitation of SHR neurons was blocked or antagonized by simultaneous application of saralasin, evoked at significantly lower thresholds and displayed exaggerated periods of postactivity compared to OVLT neurons in preparations taken from WKY controls. Neuronal responses tol-glutamate were similar between the two rat strains. Differences in neuronal sensitivity to AII may be causally linked to hypertension in SHR.