Serotonin and the evaluation of future rewards - Theory, experiments, and possible neural mechanisms
Serotonin and the evaluation of future rewards - Theory, experiments, and possible neural mechanisms
复制标题
DOI：
10.1196/annals.1390.011
复制
发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Doya, Kenji
中科院分区：
文献类型：
--
作者：
Schweighofer, Nicolas;Tanaka, Saori C.;Doya, Kenji
通过考虑延迟和奖励结果的数量来选择行动的能力对于动物和人类的生存和福祉至关重要。先前的动物实验表明，血清素通过调节延迟奖励的评估在行动选择中发挥作用。然而，目前还不清楚5-羟色胺是通过哪些神经回路、哪些受体和细胞内机制影响延迟奖励的评价的。在这里，我们回顾实验研究和计算理论的决定下延迟奖励，并提出，5-羟色胺控制的时间尺度的奖励预测通过调节基底神经节的神经活动。
The ability to select an action by considering both delays and amount of reward outcome is critical for survival and well-being of animals and humans. Previous animal experiments suggest a role of serotonin in action choice by modulating the evaluation of delayed rewards. It remains unclear, however, through which neural circuits, and through what receptors and intracellular mechanisms, serotonin affects the evaluation of delayed rewards. Here, we review experimental studies and computational theory of decisions under delayed rewards, and propose that serotonin controls the timescale of reward prediction by regulating neural activity in the basal ganglia.