Molecular and cellular immune responses to ischemic brain injury.
Molecular and cellular immune responses to ischemic brain injury.
复制标题
DOI：
10.1007/s12975-014-0349-7
复制
发表时间：
2014-10
影响因子：
6.9
通讯作者：
Pennypacker, Keith R.
中科院分区：
文献类型：
--
作者：
Seifert, Hilary A.;Pennypacker, Keith R.
尽管对中风病理学进行了广泛的研究，但最近在中风治疗方面没有任何重大进展。脑缺血的动物模型和临床数据已被用于研究初始缺血性损伤后发生的进行性神经损伤。这使得研究人员更加关注脑缺血引起的外周免疫反应。迄今为止，这项研究开发的疗法在临床试验中证明无效。这些疗法在临床试验中的失败被认为是由于治疗引起的广泛免疫抑制和脑缺血本身。新出现的证据表明，中风后对免疫系统进行更有选择性的调节可能是有益的。脾脏已被证明会加剧实验性中风后的神经损伤，并将提供一个强有力的治疗靶点。选择免疫系统的靶向方面将允许免疫反应的保护和再生特性保持完整，同时减弱对受伤大脑产生的促炎反应。
Despite extensive research into stroke pathology, there have not been any major recent advancements in stroke therapeutics. Animal models of cerebral ischemia and clinical data have been used to investigate the progressive neural injury that occurs after an initial ischemic insult. This has lead researchers to focus more on the peripheral immune response that is generated as a result of cerebral ischemia. The therapies that have been developed as a result of this research thus far have proven ineffective in clinical trials. The failure of these therapeutics in clinical trials is thought to be due to the broad immunosuppression elicited as a result of the treatments and the cerebral ischemia itself. Emerging evidence indicates a more selective modulation of the immune system following stroke could be beneficial. The spleen has been shown to exacerbate neural injury following experimental stroke and would provide a strong therapeutic target. Selecting facets of the immune system to target would allow the protective and regenerative properties of the immune response to remain intact while blunting the pro-inflammatory response generated towards the injured brain.
登录
查看更多内容
影响因子：
14.5
作者：
Gertz, Karen;Kronenberg, Golo;Endres, Matthias
通讯作者：
Endres, Matthias
影响因子：
6.3
作者：
Becker, KJ;Kindrick, DL;Ye, ZC
通讯作者：
Ye, ZC
影响因子：
4.7
作者：
de Bilbao, Fabienne;Arsenijevic, Denis;Giannakopoulos, Panteleimon
通讯作者：
Giannakopoulos, Panteleimon
影响因子：
8.3
作者：
Becker KJ;Kalil AJ;Tanzi P;Zierath DK;Savos AV;Gee JM;Hadwin J;Carter KT;Shibata D;Cain KC
通讯作者：
Cain KC
DOI：
10.1097/01.wcb.0000055177.50448.fa
发表时间：
2003-04-01
影响因子：
6.3
作者：
Herrmann, O;Tarabin, V;Schwaninger, M
通讯作者：
Schwaninger, M