Longitudinal Myocardial Deformation is Selectively Decreased After Pediatric Cardiac Transplantation: A Comparison of Children 1 Year After Transplantation With Normal Subjects Using Velocity Vector Imaging
Longitudinal Myocardial Deformation is Selectively Decreased After Pediatric Cardiac Transplantation: A Comparison of Children 1 Year After Transplantation With Normal Subjects Using Velocity Vector Imaging
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DOI：
10.1007/s00246-012-0205-z
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发表时间：
2012-06-01
影响因子：
1.6
通讯作者：
Landeck, Bruce F.
中科院分区：
文献类型：
--
作者：
Kailin, Joshua A.;Miyamoto, Shelley D.;Landeck, Bruce F.
移植心脏在心脏移植期间和之后经历了许多血流动力学变化。本研究旨在利用速度矢量成像（VVI）评估儿童心脏移植人群的左心室心肌力学。本研究回顾性评价了28例心脏移植术后12个月的超声心动图。用28名年龄和性别匹配的受试者的超声心动图作为对照组。获得左心室纵向和周向应变、收缩应变率和舒张应变率的峰值。使用学生t检验来评估两组之间的差异（定义为p千分之一货币符号0.05）。移植组左室纵向应变峰值（17.21%）低于对照组（22.14%）。移植组和对照组的峰值全球周向菌株没有显著差异（分别为20.28%和20.79%）。类似的结果被观察到纵向和圆周收缩和舒张应变率。与对照组相比，移植患者在所有全球纵向测量中显示出统计学上显著的降低。移植受者似乎保留了心肌的周向变形。鉴于已知的心肌纤维向心内膜表面的纵向纤维排列，这也在冠状动脉的远端，这可能是缺血的证据。
The transplanted heart experiences numerous hemodynamic changes during and after cardiac transplantation. This study sought to evaluate the left ventricular myocardial mechanics in the pediatric heart transplant population using Velocity Vector Imaging (VVI). This study retrospectively evaluated 28 heart transplant recipients by echocardiography 12 months after transplantation. Echocardiograms from 28 age- and gender-matched subjects were used as a control group. Peak global longitudinal and circumferential left ventricular strain, systolic strain rate, and diastolic strain rate were obtained. Student's t tests were used to assess differences between the two groups (defined as p a parts per thousand currency sign 0.05). The peak global left ventricular longitudinal strain was lower in the transplant group (17.21%) than in the control group (22.14%). The transplant and control groups did not differ significantly in terms of their peak global circumferential strain (20.28% vs. 20.79%, respectively). Similar results were observed for longitudinal and circumferential systolic and diastolic strain rates. The transplant patients showed statistically significant reductions in all peak global longitudinal measures compared with those of the control subjects. Circumferential myocardial deformation appears to be preserved in transplant recipients. This could suggest evidence of ischemia given the known myocardial fiber arrangement of longitudinal fibers toward the endocardial surface, which is also more distal in the coronary arterioles.