SERUM INSULIN-LIKE GROWTH FACTOR-I IN 1030 HEALTHY-CHILDREN, ADOLESCENTS, AND ADULTS - RELATION TO AGE, SEX, STAGE OF PUBERTY, TESTICULAR SIZE, AND BODY-MASS INDEX
SERUM INSULIN-LIKE GROWTH FACTOR-I IN 1030 HEALTHY-CHILDREN, ADOLESCENTS, AND ADULTS - RELATION TO AGE, SEX, STAGE OF PUBERTY, TESTICULAR SIZE, AND BODY-MASS INDEX
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DOI：
10.1210/jc.78.3.744
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发表时间：
1994-03-01
影响因子：
5.8
通讯作者：
SKAKKEBAEK, NE
中科院分区：
文献类型：
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作者：
JUUL, A;BANG, P;SKAKKEBAEK, NE
血清胰岛素样生长因子-I（IGF-I）水平随年龄和青春期发育而增加。在正常情况下，循环中IGF-I水平的巨大变化使得难以使用单个儿童的IGF-I值来评估其生长状况。此外，在许多IGF-I测定中IGF结合蛋白的干扰也导致了这个问题。我们测量了1030名健康儿童、青少年和成人的酸乙醇提取血清中的IGF-I，使用RIA，通过使用单碘化Tyr（31）-[I-125]des-（1-3）IGF-I作为放射性配体来减少IGF结合蛋白的干扰。L，在青春期进一步急剧增加至约500 μ g/L。青春期后，循环IGF-I水平在整个成年期明显持续下降，80岁时平均为100 μ g/L（P < 0.0001）。女孩在14.5岁时IGF-I水平最高，而男孩在1年后达到IGF-I水平峰值。这比平均高度流速峰值晚了近2年。当根据性别和青春期坦纳阶段分离数据时，青春期血清IGF-I水平的巨大变化减少。有趣的是，我们发现在坦纳期内，血清IGF-I浓度随年龄的增长而显著变化;在青春期早期，血清IGF-I浓度随年龄的增长而增加，在青春期晚期，血清IGF-I浓度随年龄的增长而降低（P < 0.05）。血清IGF-I随着睾丸体积的增加而增加。多元回归分析显示血清IGF-I水平可预测术后1年身高增长速度（r = 0.33; P < 0.0001）。多元回归分析显示，青春期前儿童的体重指数与血清IGF-I无显着相关性。总之，除了众所周知的随着年龄或青春期阶段的增加而增加之外，血清IGF-I水平在青春期的特定坦纳阶段内还随着年龄的增长而显着变化。因此，在横断面设计中研究1030名儿童时，性别、年龄和青春期对血清IGF-I的影响不能被分离成简单的相加成分。因此，年龄，性别和青春期校正的IGF-I值，事实上，可以提高使用血清IGF-I作为诊断工具，以区分青春期发育迟缓的儿童和GH缺乏的个人。
Serum levels of insulin-like growth factor-I (IGF-I) increase with age and pubertal development. The large variation in circulating IGF-I levels in adolesence makes it difficult to use the IGF-I value of a single child in the assesment of his growth status. In addition, the interference of IGF-binding proteins in many IGF-I assays contributes to this problem. We measured IGF-I in acid-ethanol-extracted serum from 1030 healthy children, adolescents, and adults, employing a RIA that reduces interference of IGF-binding proteins by using monoiodinated Tyr(31)-[I-125]des-(1-3)IGF-I as radioligand.Mean serum IGF-I concentrations increased slowly in prepubertal children from 80-200 mu g/L with a further steep increase during puberty to approximately 500 mu g/L. After puberty, a subsequent continuous fall in circulating IGF-I levels was apparent throughout adulthood to a mean of 100 mu g/L at the age of 80 yr (P < 0.0001). Girls had maximal IGF-I levels at 14.5 yr of age, whereas boys had peak IGF-I levels 1 yr later. This is almost 2 yr later than average peak height velocity. The large variation in serum IGF-I levels during puberty was diminished when data were separated according to sex and Tanner stage of puberty. Interestingly, we found a significant variation with age within the Tanner stages; there was an increase in serum IGF-I concentrations with age in the early pubertal stages and a decrease in the late stages (P < 0.05). Serum IGF-I increased concomitantly with increasing testicular volume. Multiple regression analysis revealed that serum IGF-I levels predicted height velocity in the following year (r = 0.33; P < 0.0001). Body mass index did not correlate significantly with serum IGF-I in prepubertal children in a multiple regression analysis.In conclusion, there was a significant variation in serum IGF-I levels with age within a given Tanner stage of puberty in addition to the well known increase with increasing age or pubertal stage. Accordingly, the effects of sex, age, and puberty on serum IGF-I cannot be separated into simple additive components when studying 1030 children in a cross-sectional design. Thus, the age-, sex-, and puberty-corrected IGF-I values may, in fact, improve the use of serum IGF-I as a diagnostic tool to distinguish between a child with retarded puberty and a GH-deficient individual.