Interactions between malaria parasites and their mosquito hosts in the midgut
Interactions between malaria parasites and their mosquito hosts in the midgut
复制标题
DOI：
10.1016/j.ibmb.2004.03.026
复制
发表时间：
2004-07-01
影响因子：
3.8
通讯作者：
Louis, C
中科院分区：
文献类型：
--
作者：
Siden-Kiamos, I;Louis, C
这篇综述研究了目前已知的疟原虫和按蚊之间的分子相互作用，这种相互作用在通过感染性血粉摄入寄生虫后在后者的中肠中发生。为了在肠道中“定居”并转化为产生子孢子的卵囊，疟原虫需要经历不同的发育步骤，这些步骤的特征通常是使用蚊子媒介提供的选定资源。此外，寄生虫可能会利用其中一些资源来克服昆虫宿主的防御机制。目前正在对疟原虫和蚊子的这种相互作用的分子伙伴进行定义和分析，从而了解它们；这些将在这里详细介绍。 (C) 2004 年，爱思唯尔有限公司出版。
This review examines what is presently known of the molecular interactions between Plasmodium and Anopheles that take place in the latter's midgut upon ingestion of the parasites with an infectious blood meal. In order to become 'established' in the gut and to transform into a sporozoite-producing oocyst, the malaria parasite needs to undergo different developmental steps that are often characterized by the use of selected resources provided by the mosquito vector. Moreover, some of these resources may be used by the parasite in order to overcome the insect host's defence mechanisms. The molecular partners of this interplay are now in the process of being defined and analyzed for both Plasmodium and mosquito and, thus, understood; these will be presented here in some detail. (C) 2004 Published by Elsevier Ltd.