Exploring silver nanoparticles for cancer therapy and diagnosis
Exploring silver nanoparticles for cancer therapy and diagnosis
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DOI：
10.1016/j.colsurfb.2021.112254
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发表时间：
2021-12-09
影响因子：
5.8
通讯作者：
Zucolotto, Valtencir
中科院分区：
文献类型：
--
作者：
Miranda, Renata Rank;Sampaio, Isabella;Zucolotto, Valtencir
纳米材料已成为癌症治疗和诊断的有前途的候选者，因为它们可以解决长期问题，如药物溶解度，全身分布，肿瘤获得性耐药性，并提高诊断方法的性能。在无机纳米材料中，AgNPs在癌症治疗方面已被广泛研究，报道的结果引起了令人兴奋的期望。在这篇综述中，我们提供了一个概述最近的研究AgNPs抗肿瘤特性，其在不同的癌症治疗模式中的应用，其在生物传感器开发的潜力，并强调了主要的挑战和可能的策略，使其翻译到临床使用。
Nanomaterials have emerged as promising candidates for cancer therapy and diagnosis as they can solve longterm issues such as drug solubility, systemic distribution, tumor acquired resistance, and improve the performance of diagnostic methods. Among inorganic nanomaterials, AgNPs have been extensively studied in the context of cancer treatment and the reported results have raised exciting expectations. In this review, we provide an overview of the recent research on AgNPs antitumoral properties, their application in different cancer treatment modalities, their potential in biosensors development, and also highlight the main challenges and possible strategies to enable its translation to clinical use.