Regulation and function of AMPK in physiology and diseases.
Regulation and function of AMPK in physiology and diseases.
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DOI：
10.1038/emm.2016.81
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发表时间：
2016-07-15
影响因子：
12.8
通讯作者：
Jeon SM
中科院分区：
文献类型：
--
作者：
Jeon SM
5′-腺苷一磷酸（AMP）激活的蛋白激酶（AMPK）是一种进化上保守的丝氨酸/苏氨酸激酶，最初被鉴定为维持细胞能量稳态的关键参与者。过去十年的深入研究已经确定了调节AMPK活性的多种分子机制和生理条件。AMPK调节多种代谢和生理过程，并且在主要慢性疾病如肥胖症、炎症、糖尿病和癌症中失调。基于其在生理学和病理学中的关键作用，AMPK正在成为预防和治疗这些疾病的最有前途的靶点之一。本文就AMPK的分子生理调控及其代谢和生理功能的研究进展作一综述。此外，我们还讨论了AMPK在糖尿病和癌症中的多功能作用的机制。
5′-adenosine monophosphate (AMP)-activated protein kinase (AMPK) is an evolutionarily conserved serine/threonine kinase that was originally identified as the key player in maintaining cellular energy homeostasis. Intensive research over the last decade has identified diverse molecular mechanisms and physiological conditions that regulate the AMPK activity. AMPK regulates diverse metabolic and physiological processes and is dysregulated in major chronic diseases, such as obesity, inflammation, diabetes and cancer. On the basis of its critical roles in physiology and pathology, AMPK is emerging as one of the most promising targets for both the prevention and treatment of these diseases. In this review, we discuss the current understanding of the molecular and physiological regulation of AMPK and its metabolic and physiological functions. In addition, we discuss the mechanisms underlying the versatile roles of AMPK in diabetes and cancer.