Synthesis and triplex forming properties of pyrimidine derivative containing extended functionality.
Synthesis and triplex forming properties of pyrimidine derivative containing extended functionality.
复制标题
含有扩展官能团的嘧啶衍生物的合成和三链体形成特性。
DOI：
10.1080/07328319908044841
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
McLaughlin,LW
中科院分区：
文献类型：
--
作者：
Gianolio,DA;McLaughlin,LW
Two pyrimidine nucleosides have been synthesized containing extended hydrogen bonding functionality. In one case the side chain is based upon semicarbazide and in the second monoacetylated carbohydrazide was employed. DNA sequences could be prepared using both analogue nucleosides in a reverse coupling protocol, and provided that the normal capping step was eliminated and that the iodine-based oxidizing solution was replaced with one based upon 10-camphorsulfonyl oxaziridine. Both derivatives exhibited moderate effects in targeting selectively C-G base pairs embedded within a polypurine target sequence.
