Revealing modular architecture of human brain structural networks by using cortical thickness from MRI
Revealing modular architecture of human brain structural networks by using cortical thickness from MRI
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DOI：
10.1093/cercor/bhn003
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发表时间：
2008-10-01
期刊：
影响因子：
3.7
通讯作者：
Evans, Alan C.
中科院分区：
文献类型：
--
作者：
Chen, Zhang J.;He, Yong;Evans, Alan C.
模块化大概是受到进化限制的影响，是从社交网络到生物网络等最复杂网络功能的基础。然而，它在人类皮质网络中仍然很大程度上未知。在之前的一项研究中，我们展示了特定皮质区域之间的皮质厚度相关性网络，并推测这些相关性反映了这些大脑区域之间的潜在结构连接性。在这里，我们进一步研究了源自皮质厚度测量的人脑网络的内在模块化架构。模块被定义为在形态上连接以实现最大网络模块化的皮质区域组。我们表明，人类皮质网络被组织成 6 个拓扑模块，这些模块与已知的功能域紧密重叠，例如听觉/语言、策略/执行、感觉运动、视觉和助记处理。所确定的基于结构的模块化架构可以为皮层区域的功能和结构性大脑模块之间的连接提供新的见解。这项研究首次报告了使用皮质厚度测量的人脑结构网络的模块化架构。
Modularity, presumably shaped by evolutionary constraints, underlies the functionality of most complex networks ranged from social to biological networks. However, it remains largely unknown in human cortical networks. In a previous study, we demonstrated a network of correlations of cortical thickness among specific cortical areas and speculated that these correlations reflected an underlying structural connectivity among those brain regions. Here, we further investigated the intrinsic modular architecture of the human brain network derived from cortical thickness measurement. Modules were defined as groups of cortical regions that are connected morphologically to achieve the maximum network modularity. We show that the human cortical network is organized into 6 topological modules that closely overlap known functional domains such as auditory/language, strategic/executive, sensorimotor, visual, and mnemonic processing. The identified structure-based modular architecture may provide new insights into the functionality of cortical regions and connections between structural brain modules. This study provides the first report of modular architecture of the structural network in the human brain using cortical thickness measurements.