Assessing the outcomes of prolonged cessation-induction and aid-to-cessation trials: Floating prolonged abstinence
Assessing the outcomes of prolonged cessation-induction and aid-to-cessation trials: Floating prolonged abstinence
复制标题
DOI：
10.1093/ntr/ntp035
复制
发表时间：
2009-05-01
影响因子：
4.7
通讯作者：
Moore, David
中科院分区：
文献类型：
--
作者：
Aveyard, Paul;Wang, Dechao;Moore, David
简介：尼古丁和烟草研究学会工作组建议了戒烟诱导试验和辅助戒烟试验的结果测量。戒烟诱导试验的目的是激励不愿意戒烟的人尝试戒烟。帮助戒烟试验提供药物或行为干预，以增加自愿戒烟者成功尝试的比率。尼古丁辅助戒烟计划结合了这两种干预措施的特点，通过向不愿意戒烟的人提供尼古丁替代品，联合收割机。治疗可以延长一年以上，戒烟尝试可以在计划的早期或晚期发生并成功，重新尝试戒烟是计划的固有组成部分。传统的结果措施是绑在一个固定的，但任意点的后续行动，并不能捕捉到真正的结果：延长停止锚定的点，一个人使一个成功的戒烟attempt.Discussion：我们建议，结果应该从成功的戒烟尝试，开始在治疗期间，并持续一段时间内，理想的6个月。特别是，如果一项试验将短期复位计划与长期复位计划进行比较，则不可能使用与随访中的固定点相关的措施对此类试验的结局进行无偏倚评估。浮动长期戒烟可以提供这样的评估，适合于长期戒烟诱导试验或联合戒烟诱导和辅助戒烟试验。
Introduction: A Society for Research on Nicotine and Tobacco working group recommended outcome measures for cessation-induction trials and aid-to-cessation trials. Cessation-induction trials aim to motivate unwilling quitters to make a quit attempt. Aid-to-cessation trials give either medication or behavioral interventions to increase the rate at which willing quitters succeed in their attempts. Nicotine-assisted reduction programs combine features of both types of interventions by giving nicotine replacement to unwilling quitters. Treatment can be prolonged more than a year, quit attempts can occur and succeed early or late in the program, and renewed quit attempts are an inherent part of the program. Conventional outcome measures are tied to a fixed but arbitrary point in follow-up and cannot capture the true outcome: Prolonged cessation anchored to the point at which a person makes a successful quit attempt.Discussion: We propose that the outcome should be counted from the successful quit attempt that began during the treatment period and continues for a defined period, ideally 6 months. In particular, if a trial compared a short reduction program with a long reduction program, it would not be possible to obtain an unbiased assessment of the outcome of such a trial using a measure tied to a fixed point in follow-up. Floating prolonged abstinence could provide such an assessment and is suitable for either prolonged cessation-induction trial or combined cessation-induction and aid-to-cessation trials.