Leptin regulation of neuronal morphology and hippocampal synaptic function.
Leptin regulation of neuronal morphology and hippocampal synaptic function.
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DOI：
10.3389/fnsyn.2013.00003
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发表时间：
2013
影响因子：
3.7
通讯作者：
Harvey J
中科院分区：
文献类型：
--
作者：
Harvey J
激素瘦素在通过下丘脑调节能量稳态中的中枢作用是有据可查的。然而，越来越多的证据表明，这种激素也可以改变整个中枢神经系统突触的结构和功能。海马体是前脑的一个区域，在联想学习和记忆中起着至关重要的作用，也是一个非常容易受到神经退行性过程影响的区域。最近的研究表明，瘦素是一种潜在的认知增强剂，因为它调节的细胞过程中的树突状细胞形态，谷氨酸受体运输和活动依赖性突触可塑性依赖的海马依赖性的学习和记忆。在这里，我们回顾了最近的证据表明，激素瘦素作为一个关键的调节海马突触功能，并讨论了瘦素受体驱动的脂质信号通路参与这一过程中的作用。
The central actions of the hormone leptin in regulating energy homeostasis via the hypothalamus are well documented. However, evidence is growing that this hormone can also modify the structure and function of synapses throughout the CNS. The hippocampus is a region of the forebrain that plays a crucial role in associative learning and memory and is an area also highly vulnerable to neurodegenerative processes. Recent studies indicate that leptin is a potential cognitive enhancer as it modulates the cellular processes underlying hippocampal-dependent learning and memory including dendritic morphology, glutamate receptor trafficking and activity-dependent synaptic plasticity. Here, we review the recent evidence implicating the hormone leptin as a key regulator of hippocampal synaptic function and discuss the role of leptin receptor-driven lipid signaling pathways involved in this process.