The typical development of posterior medial frontal cortex function and connectivity during task control demands in youth 8-19years old.
The typical development of posterior medial frontal cortex function and connectivity during task control demands in youth 8-19years old.
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DOI：
10.1016/j.neuroimage.2016.05.019
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发表时间：
2016-08-15
期刊：
影响因子：
5.7
通讯作者：
Fitzgerald KD
中科院分区：
文献类型：
--
作者：
Liu Y;Angstadt M;Taylor SF;Fitzgerald KD
为了描述干扰处理和任务控制的神经基质的发展，本研究考察了年龄对干扰任务中后内侧额叶皮层的激活和连通性的线性和非线性影响。72名年龄在8 - 19岁的青少年在功能磁共振成像（fMRI）期间进行了多源干扰任务（MSIT）。随着年龄的增长，在高干扰不一致和低干扰一致试验中的总体表现变得更快和更准确。在全脑体素分析中测试了年龄对干扰-（不一致与一致条件）、错误-（不一致条件下的错误与正确试验）和总体任务处理（不一致加一致条件，相对于隐式基线）激活的影响。年龄对pMFC离散子区域的整体任务处理的激活有不同的影响：preSMA的激活随着年龄的增长而减少，而dACC的激活则与年龄相关，呈非线性（即u型）模式。preSMA与脑岛前部/额叶盖（AI/FO）的连通性随年龄增加而增加。这些发现表明，pMFC内preSMA和dACC子区域的发育存在差异。此外，随着儿童年龄的增长，preSMA激活的减少可能与preSMA- ai /FO连接的增加相结合，以支持响应任务控制需求的处理速度的提高。
To characterize the development of neural substrate for interference processing and task control, this study examined both linear and non-linear effects of age on activation and connectivity during an interference task designed to engage the posterior medial frontal cortex. Seventy-two youth, ages 8 – 19 years, performed the Multi-Source Interference Task (MSIT) during functional magnetic resonance imaging (fMRI). With increasing age, overall performance, across high-interference incongruent and low-interference congruent trials became faster and more accurate. Effects of age on activation to interference- (incongruent versus congruent conditions), error- (errors versus correct trials during the incongruent condition) and overall task-processing (incongruent plus congruent conditions, relative to implicit baseline) were tested in whole-brain voxel-wise analyses. Age differentially impacted activation to overall task processing in discrete sub-regions of the pMFC: activation in preSMA decreased with age, whereas activation in dACC followed a non-linear (i.e., U-shaped) pattern in relation to age. In addition, connectivity of preSMA with anterior insula/frontal operculum (AI/FO) increased with age. These findings suggest differential development of preSMA and dACC sub-regions within the pMFC. Moreover, as children age, decreases in preSMA activation may couple with increases in preSMA-AI/FO connectivity to support gains in processing speed in response to demands for task control.