Cooperation between monocytes and breast cancer cells promotes factors involved in cancer aggressiveness.
Cooperation between monocytes and breast cancer cells promotes factors involved in cancer aggressiveness.
复制标题
单核细胞和乳腺癌细胞之间的合作促进了涉及癌症侵袭性的因素。
DOI：
10.1038/sj.bjc.6600872
复制
发表时间：
2003-04-22
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
在乳腺癌中，诊断时肿瘤周围局部炎症的临床症状被认为具有不良预后意义。在这项研究中，单核细胞在癌症中的有害作用的生物学机制进行了调查。乳腺癌衍生的MDA-MB 231细胞与单核细胞的孵育导致参与细胞侵袭的因子（即癌细胞和单核细胞相关的尿激酶和组织因子，以及派-1和MMP-9分泌）增加。此外，单核细胞的功能也被修改。单核细胞与MDA-MB 231癌细胞的孵育导致抗增殖细胞因子Oncostatin M的分泌下调，而凋亡因子TNF α显著增加。然而，MDA-MB 231癌细胞已显示对TNF α的凋亡作用具有抗性。这些发现表明，MDA-MB 231癌细胞与单核细胞的孵育诱导了串扰，这导致参与癌细胞侵袭的因子的表达增加和单核细胞对抗癌细胞的功能的改变，同时炎症效应增加。
In breast cancers, clinical symptoms of inflammation localised around the tumour at the time of diagnosis have been considered to have poor prognosis significance. In this study, the biological mechanisms responsible for the deleterious action of monocytes in cancer were investigated. The incubation of the breast-cancer-derived MDA-MB231 cells with monocytes resulted in an increase in factors involved in cell invasion (i.e. both cancer cells and monocytes-associated urokinase and Tissue Factor, and PAI-1 and MMP-9 secretion). Moreover, the functions of monocytes were also modified. Incubation of monocytes with MDA-MB231 cancer cells resulted in a downregulation in the secretion of the antiproliferative cytokine Oncostatin M, while the apoptotic factor TNF alpha was dramatically increased. However, MDA-MB231 cancer cells have been shown to be resistant towards the apoptotic action of TNF alpha. These findings demonstrate that incubation of MDA-MB231 cancer cells with monocytes induced a crosstalk, which resulted in an increased expression of factors involved in cancer cell invasiveness and in a modification of monocytes function against cancer cells, while inflammatory effects were increased.
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影响因子：
8.4
作者：
PALANGIE, T;MOSSERI, V;POUILLART, P
通讯作者：
POUILLART, P
影响因子：
10.3
作者：
Look, MP;van Putten, WLJ;Foekens, JA
通讯作者：
Foekens, JA
影响因子：
6.2
作者：
Dimeo, FC
通讯作者：
Dimeo, FC
DOI：
10.1084/jem.148.1.223
发表时间：
1978-07-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Granelli-Piperno A;Reich E
通讯作者：
Reich E
影响因子：
5.6
作者：
ODEKON, LE;BLASI, F;RIFKIN, DB
通讯作者：
RIFKIN, DB