Changes in total body bone mineral content and regional bone mineral density in renal patients following renal transplantation.
Changes in total body bone mineral content and regional bone mineral density in renal patients following renal transplantation.
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肾移植后肾病患者全身骨矿物质含量和局部骨矿物质密度的变化。
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
J. Cunningham
中科院分区：
文献类型：
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作者：
J.T.C. Kwan;M. Almond;Kenneth R. Evans;J. Cunningham
采用双能X线骨密度仪进行全身骨矿含量(BMC)和骨密度(BMD)以及腰椎和股骨颈局部骨密度的系列测量。26名患者(15名女性和11名男性)在移植时、移植后3个月和6个月进行了研究。基线时，患者的全身骨密度和局部骨密度值与年龄和性别匹配的对照组没有显著差异。全身BMC在3个月时逐渐下降，6个月时部分恢复。术后3个月腰椎和股骨颈骨密度明显下降，6个月后无恢复迹象。这些指标的变化与移植后前3个月的住院时间有很好的相关性。这项初步研究表明，肾移植后骨骼完整性迅速恶化，这可能是进行性的。可能需要研究避免这种早期骨丢失的预防性策略。
We performed serial measurements of total body bone mineral content (BMC) and bone mineral density (BMD), and of regional BMD at the lumbar spine and femoral neck using dual energy X-ray absorptiometry. Twenty-six patients (15 females and 11 males) were studied at the time of transplantation, and 3 and 6 months post-transplant. At baseline, the total body BMC and regional BMD values of the patients did not differ significantly from age- and sex-matched controls. Total body BMC had fallen progressively at 3 months, followed by partial recovery at 6 months. Significant decreases of BMD were seen in the lumbar spine and femoral neck at 3 months with no evidence of recovery at 6 months. The changes in these indices correlated well with the duration of hospital stay in the first 3 post-transplant months. This preliminary study demonstrated rapid deterioration of skeletal integrity following renal transplantation and that this might be progressive. Preventative strategies to avoid this early bone loss may need to be investigated.