YAP-(S)PET small animal scanner: Quantitative results
YAP-(S)PET small animal scanner: Quantitative results
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DOI：
10.1109/tns.2003.817970
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发表时间：
2003-10-01
影响因子：
1.8
通讯作者：
Del Guerra, A
中科院分区：
文献类型：
--
作者：
Di Domenico, G;Zavattini, G;Del Guerra, A
费拉拉大学的YAP-(S)PET扫描仪目前被用于小动物SPECT研究，使用Tc-99 m标记的放射性示踪剂，目的是通过对大鼠重建图像的感兴趣区域（ROI）分析获得定量活性测量。测量结果将直接与传统的伽马计数器的离体活性测量进行比较。为了实现这一目标，扫描仪相对于标准等剂量剂量校准器进行校准，标准等剂量剂量校准器使用各种经认证的活度源进行校准。校正因子K定义为等剂量测定活度（MBq）与图像计数率（cps）之比。我们发现K = 0.1346 +/- 0.0008 MBq/cps，在广泛的活动范围内（9-88 MBq）具有良好的线性关系。通过校准的扫描仪，我们比较了整个大鼠心脏图像与切除心脏图像的活动测量结果。我们发现两次测量结果很吻合。
The University of Ferrara YAP-(S)PET scanner is currently being employed in small animal SPECT studies, with Tc-99 m labeled radiotracers, with the goal of obtaining quantitative activity measurements from region of interest (ROI) analysis of reconstructed images of rats. The measurements will be compared directly with traditional ex vivo measurement of activity with gamma counters. To achieve this goal, the scanner was calibrated relative to a standard Isodose dose calibrator which was calibrated with various certified activity sources. The calibration factor K was defined as the ratio of the activity measured with the Isodose (MBq) and the image count rate (cps). We find K = 0.1346 +/- 0.0008 MBq/cps, with good linearity over a wide range of activities (9-88 MBq). With the calibrated scanner we compared results of activity measurements from images of whole-rat heart acquisitions versus excised hearts. We found good agreement between the two measurements.