Interferon-β administration confers a beneficial outcome in a rabbit model of thromboembolic cerebral ischemia
Interferon-β administration confers a beneficial outcome in a rabbit model of thromboembolic cerebral ischemia
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DOI：
10.1016/s0304-3940(02)00371-3
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发表时间：
2002-07-19
影响因子：
2.5
通讯作者：
Tan, YH
中科院分区：
文献类型：
--
作者：
Liu, HP;Xin, LX;Tan, YH
我们证明，细胞因子人干扰素-β(干扰素-β)的治疗在兔血栓栓塞性脑缺血模型中产生了有益的结果。在将自体血栓引入大脑中动脉之前(前)或之后(治疗后)，皮下注射干扰素-β的兔与对照组(未治疗)相比，皮质下梗塞体积一直较小。治疗前脑皮质下梗塞体积为46.3+/-9.3 mm(3)(n=4)，治疗后为40.0+/-23.1 mm(3)。与对照组(121.6±32.9mm3，n=5)相比，两者均显著缩小(P=0.003和P=0.004)。尽管干扰素-β对中风有益作用的确切机制尚不清楚，但我们的结果与已知的干扰素-β的抗炎和抗凋亡功能是一致的。(C)2002爱思唯尔科学爱尔兰有限公司。保留所有权利。
We demonstrate that treatment with the cytokine human interferon-beta (IFN-beta) resulted in a beneficial outcome in a rabbit model of thromboembolic cerebral ischemia. Rabbits administered subcutaneously with IFN-beta prior to (pretreatment) or after (post-treatment) the introduction of an autologous blood clot into the middle cerebral artery have consistently smaller subcortical infarct volumes compared to control (untreated) counterparts. The average subcortical infarct volume of pre-treatment rabbits is 46.3 +/- 9.3 mm(3) (n = 4), and that of post-treatment rabbit is 40.0 +/- 23.1 mm(3) (n = 4). Both are significantly lower (P = 0.003 and P = 0.004, respectively) than the average subcortical infarct volume of control rabbits (121.6 +/- 32.9 mm(3), n = 5). Although the precise mechanism responsible for the beneficial effect of IFN-beta on stroke is not yet clear, our results are in line with the known anti-inflammatory potential and anti-apoptotic function of IFN-beta. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.