Estimation of the extent of linkage disequilibrium in seven regions of the porcine genome
Estimation of the extent of linkage disequilibrium in seven regions of the porcine genome
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DOI：
10.1081/abio-200053402
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发表时间：
2005-01-01
影响因子：
3.7
通讯作者：
Pas, MFWT
中科院分区：
文献类型：
--
作者：
Jungerius, BJ;Gu, JJ;Pas, MFWT
连锁不平衡（LD）是指相邻等位基因之间的相关性，反映了（附近）基因座上等位基因之间的非随机关联模式。更好地了解LD在猪基因组中是直接相关的基因和突变的鉴定与感兴趣的characteristics.There，215 SNPs在7个基因组区域在3个品种的个体进行基因分型。计算所有标记对的成对连锁不平衡。为了估计LD的程度，将所有成对LD值相对于标记物之间的距离作图。基于在来自大白色、荷兰长白猪和梅山猪的三个群体中分析的四个基因组区域中的SNP标记，估计有用的LD在猪基因组中延伸约40至60 kb。
Linkage disequilibrium (LD) refers to the correlation among neighboring alleles, reflecting non-random patterns of association between alleles at (nearby) loci. A better understanding of LD in the porcine genome is of direct relevance for identification of genes and mutations with a certain effect on the traits of interest.Here, 215 SNPs in seven genomic regions were genotyped in individuals of three breeds. Pairwise linkage disequilibrium was calculated for all marker pairs. To estimate the extent of LD, all pairwise LD values were plotted against the distance between the markers. Based on SNP markers in four genomic regions analyzed in three panels from populations of Large White, Dutch Landrace, and Meishan origin, useful LD is estimated to extend for approximately 40 to 60 kb in the porcine genome.