A printable active network actuator built from an engineered biomolecular motor
A printable active network actuator built from an engineered biomolecular motor
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DOI：
10.1038/s41563-021-00969-6
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发表时间：
2021-04-19
期刊：
影响因子：
41.2
通讯作者：
Hiratsuka, Yuichi
中科院分区：
文献类型：
--
作者：
Nitta, Takahiro;Wang, Yingzhe;Hiratsuka, Yuichi
由生物分子马达和细丝组成的图案收缩网络在光触发的分子刺激下实现了毫米级机械结构的驱动。以可控的方式利用单个分子马达的运动和力来执行宏观任务可以为包括机器人在内的许多应用提供实质性的好处。然而，尽管合成和生物分子马达已经证明了毫米级的运动，但将它们有效地集成到执行宏观任务的工程系统中仍然具有挑战性。在这里，我们描述了一个能够宏观驱动的主动网络，它由工程驱动蛋白、生物分子马达和微管分层组装而成，类似于肌肉中的收缩单元。这些收缩材料可以在需要的区域使用有图案的紫外线照明形成，允许它们结合到机械工程系统中，也与印刷技术兼容。由于设计了丝状的动力总成，产生的力达到微牛顿范围，可以驱动毫米级的机械部件。这些特性可能对制造具有高级功能的软机器人系统有用。
Patterned contracting networks composed of biomolecular motors and filaments achieve millimetre-scale actuation of mechanical structures with light-triggered molecular stimuli.Leveraging the motion and force of individual molecular motors in a controlled manner to perform macroscopic tasks can provide substantial benefits to many applications, including robotics. Nonetheless, although millimetre-scale movement has been demonstrated with synthetic and biological molecular motors, their efficient integration into engineered systems that perform macroscopic tasks remains challenging. Here, we describe an active network capable of macroscopic actuation that is hierarchically assembled from an engineered kinesin, a biomolecular motor, and microtubules, resembling the contractile units in muscles. These contracting materials can be formed in desired areas using patterned ultraviolet illumination, allowing their incorporation into mechanically engineered systems, being also compatible with printing technologies. Due to the designed filamentous assembly of kinesins, the generated forces reach the micronewton range, enabling actuation of millimetre-scale mechanical components. These properties may be useful for the fabrication of soft robotic systems with advanced functionalities.