Luminomagnetic Eu3+- and Dy3+-doped hydroxyapatite for multimodal imaging.
Luminomagnetic Eu3+- and Dy3+-doped hydroxyapatite for multimodal imaging.
复制标题
DOI：
10.1016/j.msec.2017.08.032
复制
发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Annemarie Tesch;C. Wenisch;K. Herrmann;J. Reichenbach;P. Warncke;D. Fischer;F. Müller
中科院分区：
文献类型：
--
作者：
Annemarie Tesch;C. Wenisch;K. Herrmann;J. Reichenbach;P. Warncke;D. Fischer;F. Müller
多模态成像最近由于不同成像模态（如光致发光（PL）和磁共振成像（MRI））的有利组合而吸引了很多关注。本研究通过掺杂铕（Eu 3+）和镝（Dy 3+）制备了发光和磁性羟基磷灰石（HAp）。Eu 3+和Dy 3+的共掺杂用于联合收割机组合期望的物理性质。两种镧系元素离子都成功地掺入HAp晶格中，在那里它们优先占据钙（I）位点。当Eu掺杂的HAp（Eu：HAp）表现出掺杂浓度依赖的持久PL特性时，Dy掺杂的HAp（Dy：HAp）由于Dy 3+的高磁矩而表现出顺磁行为。共掺杂HAp（Eu：Dy：HAp）纳米颗粒联合收割机在一个单晶中结合了这两种性质。值得注意的是，多峰共掺杂HAp的特征在于增强的PL性质，这是由于从Dy 3+敏化剂到Eu 3+激活剂离子的能量转移。Eu：Dy：HAp具有很强的横向弛豫效应，最大横向弛豫率为83.3L/（mmol·s）。由于它们的可调PL、磁性和细胞相容性，Eu：-、Dy：-和Eu：Dy：HAp代表了用于发光成像的有前景的生物相容性陶瓷材料，其同时可以用作永久植入物或功能涂层中的MRI的造影剂。
Multimodal imaging has recently attracted much attention due to the advantageous combination of different imaging modalities, like photoluminescence (PL) and magnetic resonance imaging (MRI). In the present study, luminescent and magnetic hydroxyapatites (HAp) were prepared via doping with europium (Eu3 +) and dysprosium (Dy3 +), respectively. Co-doping of Eu3 +and Dy3 +was used to combine the desired physical properties. Both lanthanide ions were successfully incorporated in the HAp crystal lattice, where they preferentially occupied calcium(I) sites. While Eu-doped HAp (Eu:HAp) exhibits dopant concentration dependent persistent PL properties, Dy-doped HAp (Dy:HAp) shows paramagnetic behavior due to the high magnetic moment of Dy3 +. Co-doped HAp (Eu:Dy:HAp) nanoparticles combine both properties in one single crystal. Remarkably, multimodal co-doped HAp features enhanced PL properties due to an energy transfer from Dy3 +sensitizer to Eu3 +activator ions. Eu:Dy:HAp exhibits strong transverse relaxation effects with a maximum transverse relaxivity of 83.3 L/(mmol·s). Due to their tunable PL, magnetic properties and cytocompatibility Eu:-, Dy:- and Eu:Dy:HAp represent promising biocompatible ceramic materials for luminescence imaging that simultaneously may serve as a contrast agent for MRI in permanent implants or functional coatings.