Impact & Blast Traumatic Brain Injury: Implications for Therapy
Impact & Blast Traumatic Brain Injury: Implications for Therapy
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影响
作者：
Satoshi Yamamoto;D. Dewitt;D. Prough
创伤性脑损伤 (TBI) 是伊拉克自由行动 (OIF)、持久自由行动 (OEF) 和新黎明行动 (OND) 中最常见的战斗伤亡原因之一。尽管爆炸事故不如战斗中的爆炸事故那么常见，但美国仍有大量平民遭受爆炸伤害。目前美国国防部 (DoD) 医疗保健系统中的 ICD-9 衍生 TBI 诊断显示，2016 年，在 13,634 例脑损伤总数中，重度和中度 TBI 分别仅占 0.7% 和 12.9%，而轻度 TBI (mTBI) 占总数的 86%。尽管有报告称急变性创伤性脑损伤和非急变性创伤性脑损伤之间的长期并发症发生率存在差异，但临床表现是按严重程度评分而不是机制进行分类，因为严重程度评分与临床实践中的预后相关。爆炸性脑外伤 (bTBI) 的病理学和机制是独特的，但没有针对 bTBI 的特异性治疗方法——这些患者的治疗方法与一般 TBI 类似，并且治疗是根据个体情况量身定制的。目前尚无基于证据的临床指南推荐的神经保护药物。
Traumatic brain injury (TBI) is one of the most frequent causes of combat casualties in Operations Iraqi Freedom (OIF), Enduring Freedom (OEF), and New Dawn (OND). Although less common than combat-related blast exposure, there have been significant numbers of blast injuries in civilian populations in the United States. Current United States Department of Defense (DoD) ICD-9 derived diagnoses of TBI in the DoD Health Care System show that, for 2016, severe and moderate TBIs accounted for just 0.7% and 12.9%, respectively, of the total of 13,634 brain injuries, while mild TBIs (mTBIs) accounted for 86% of the total. Although there is a report that there are differences in the frequency of long-term complications in mTBI between blast and non-blast TBIs, clinical presentation is classified by severity score rather than mechanism because severity scoring is associated with prognosis in clinical practice. Blast TBI (bTBI) is unique in its pathology and mechanism, but there is no treatment specific for bTBIs—these patients are treated similarly to TBIs in general and therapy is tailored on an individual basis. Currently there is no neuroprotective drug recommended by the clinical guidelines based on evidence.
影响因子：
6.2
作者：
Wright, David W.;Kellermann, Arthur L.;Stein, Donald G.
通讯作者：
Stein, Donald G.
北卡罗来纳州高中运动员脑震荡的发病率和危险因素，1996-1999 年。
DOI：
10.1093/aje/kwh304
发表时间：
2004
期刊：
American journal of epidemiology.
影响因子：
--
作者：
Schulz,MarkR;Marshall,StephenW;Mueller,FrederickO;Yang,Jingzhen;Weaver,NancyL;Kalsbeek,WilliamD;Bowling,JMichael
通讯作者：
Bowling,JMichael