Association of longitudinal changes in quality of life with comorbidities and exacerbations in patients with severe asthma
Association of longitudinal changes in quality of life with comorbidities and exacerbations in patients with severe asthma
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DOI：
10.1016/j.alit.2022.05.009
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发表时间：
2022-09-23
影响因子：
6.8
通讯作者：
Konno, Satoshi
中科院分区：
文献类型：
--
作者：
Matsumoto-Sasaki, Machiko;Suzuki, Masaru;Konno, Satoshi
背景资料：生活质量（QoL）评估在重度哮喘的管理中很重要，合并症和/或急性发作可能影响纵向QoL。然而，很少有关于哮喘患者多年生活质量的纵向评估及其相关因素的报道。本研究的目的是澄清在长期观察期间在严重asthma.Methods患者的合并症和/或急性加重的纵向生活质量变化的关系：共105例受试者参加了北海道为基础的调查性队列分析难治性哮喘（Hi-CARAT）与6年的随访进行了分析。使用标准化哮喘生活质量问卷每年评估一次生活质量，受试者分为三组：（1）生活质量持续良好，（2）生活质量持续较差，（3）生活质量波动。评估的合并症包括抑郁症，胃食管反流病，过度白天嗜睡（EDS），阻塞性睡眠呼吸暂停的一个关键症状。结果：105例严重哮喘，53（50%）被归类为持续良好的生活质量组，10（10%）在持续不良生活质量组，42（40%）在波动的生活质量组。生活质量持续较差组与因急性加重和存在多种合并症而住院的时间较短相关。此外，EDS的存在是一个独立的贡献者波动的QoL组相比，持续良好的QoL group.Conclusions：存在多种合并症和住院治疗，由于急性加重有助于纵向变化，生活质量在重度哮喘患者。版权所有（c）2022，日本变态反应学会。制作和托管由Elsevier B. V.这是一个开放获取的文章在CC BY-NC-ND许可证（http：//creativecommons.org/licenses/by-nc-nd/4.0/）。
Background: Quality of life (QoL) assessment is important in the management of severe asthma, and comorbidities and/or exacerbations may affect longitudinal QoL. However, there are few reports on the longitudinal assessment of QoL in patients with asthma over multiple years and its related factors. This study aimed to clarify the relationship of longitudinal changes in QoL with comorbidities and/or exacerbations during a prolonged observation period in patients with severe asthma.Methods: A total of 105 subjects who participated in the Hokkaido-based Investigative Cohort Analysis for Refractory Asthma (Hi-CARAT) with a six-year follow-up were analyzed. QoL was assessed annually, using the Standardized Asthma Quality of Life Questionnaire, and the subjects were divided into three groups: (1) persistently good QoL, (2) persistently poor QoL, and (3) fluctuating QoL. Assessed comorbidities comprised depression, gastroesophageal reflux disease, and excessive daytime sleepiness (EDS), a key symptom of obstructive sleep apnea.Results: Of 105 subjects with severe asthma, 53 (50%) were classified in the persistently good QoL group, 10 (10%) in the persistently poor QoL group, and 42 (40%) in the fluctuating QoL group. The persistently poor QoL group was associated with shorter time to hospitalization due to exacerbation and the presence of multiple comorbidities. In addition, the presence of EDS was an independent contributor to the fluctuating QoL group compared to the persistently good QoL group.Conclusions: The presence of multiple comorbidities and hospitalization due to exacerbation contribute to longitudinal changes in QoL in patients with severe asthma. Copyright (c) 2022, Japanese Society of Allergology. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).