PLATELET-ACTIVATING-FACTOR AS A POTENTIAL RETROGRADE MESSENGER IN CA1 HIPPOCAMPAL LONG-TERM POTENTIATION
PLATELET-ACTIVATING-FACTOR AS A POTENTIAL RETROGRADE MESSENGER IN CA1 HIPPOCAMPAL LONG-TERM POTENTIATION
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DOI：
10.1038/367175a0
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发表时间：
1994-01-13
期刊：
影响因子：
64.8
通讯作者：
ZORUMSKI, CF
中科院分区：
文献类型：
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作者：
KATO, K;CLARK, GD;ZORUMSKI, CF
长时程增强(LTP)是指在某些突触被高频激活后，神经传递的持续增强1。虽然突触前和突触后的机制都有助于LTP2，3，但人们认为，伴随这一过程的神经递质的增强释放是由于突触后神经元产生了一种可扩散的信使，该信使穿过突触间隙，改变了突触前终末的功能。花生四烯酸是这种信使的一个候选者，它是磷脂酶A2产生的一种代谢产物，当与突触前刺激结合时，它会增强突触传递。然而，花生四烯酸的作用需要激活N-甲基-D-天冬氨酸的突触后受体。此前我们发现，血小板激活因子(1 O-alkyl-2-acetyl-sn-glycero-3-phosphocholine)，)是另一种磷脂酶A2衍生的信使7，通过突触前机制选择性地增强海马神经元的兴奋性突触后电流。我们现在提出的证据表明，血小板激活因子作用于突触区域的受体，参与大鼠海马片CA1区的LTP，并可能作为逆行信号级联的一部分。
LONG-term potentiation (LTP) refers to a persisting enhancement of neurotransmission that follows high-frequency activation of certain synapses1. Although both pre- and postsynaptic mechanisms contribute to LTP2,3, it is believed that the enhanced release of neurotransmitter that accompanies this process results from the production of a diffusible messenger in postsynaptic neurons which traverses the synaptic cleft and alters the function of presynaptic terminals4,5. One candidate for such a messenger is arachidonic acid, a metabolite produced by phospholipase A2 which augments synaptic transmission when coupled with presynaptic stimulations. However, the effects of arachidonic acid require activation of the postsynaptic receptor for N-methyl-D-aspartate6. Previously we found that platelet-activating factor (1 O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), another phospholipase A2-derived messenger7, selectively enhances excitatory postsynaptic currents in hippocampal neurons by a presynaptic mechanism8. We now present evidence that platelet-activating factor, acting at a receptor localized to synaptic regions, participates in LTP in the CA1 region of rat hippocampal slices and may serve as part of a retrograde signalling cascade.