Long Non-Coding RNAs in Vascular Inflammation.
Long Non-Coding RNAs in Vascular Inflammation.
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DOI：
10.3389/fcvm.2018.00022
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发表时间：
2018
影响因子：
3.6
通讯作者：
Feinberg MW
中科院分区：
文献类型：
--
作者：
Haemmig S;Simion V;Feinberg MW
不到2%的基因组编码蛋白质。越来越多的研究揭示了来自非编码基因组的多种rna。其中，长链非编码rna （lncRNAs）近年来作为包括心血管疾病（CVD）在内的多种生物过程的新兴调控因子而受到广泛关注。然而，我们对它们控制cvd相关基因表达和细胞信号通路的机制的了解仍然有限。此外，只有少数lncrna在血管炎症的背景下进行了功能评估，血管炎症是急性和慢性疾病状态的重要基础。由于一些lncrna可能以细胞和组织特异性表达模式表达，因此这些非编码rna作为新的生物标志物和健康和疾病的治疗靶点具有很大的前景。在此，我们回顾了那些参与急性和慢性血管炎症的促炎和抗炎过程的lncrna。对血管炎症中lncrna的进一步了解可能为CVD的病理生理学提供新的见解，并为产生一类新的基于rna的生物标志物和治疗靶点提供机会。
Less than 2% of the genome encodes for proteins. Accumulating studies have revealed a diverse set of RNAs derived from the non-coding genome. Among them, long non-coding RNAs (lncRNAs) have garnered widespread attention over recent years as emerging regulators of diverse biological processes including in cardiovascular disease (CVD). However, our knowledge of their mechanisms by which they control CVD-related gene expression and cell signaling pathways is still limited. Furthermore, only a handful of lncRNAs has been functionally evaluated in the context of vascular inflammation, an important process that underlies both acute and chronic disease states. Because some lncRNAs may be expressed in cell- and tissue-specific expression patterns, these non-coding RNAs hold great promise as novel biomarkers and as therapeutic targets in health and disease. Herein, we review those lncRNAs implicated in pro- and anti-inflammatory processes of acute and chronic vascular inflammation. An improved understanding of lncRNAs in vascular inflammation may provide new pathophysiological insights in CVD and opportunities for the generation of a new class of RNA-based biomarkers and therapeutic targets.