The puzzle of ploidy of Purkinje neurons
The puzzle of ploidy of Purkinje neurons
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DOI：
10.1080/14734220500435894
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发表时间：
2006-03-01
期刊：
影响因子：
3.5
通讯作者：
Del Monte, U
中科院分区：
文献类型：
--
作者：
Del Monte, U
本文对文献中存在的关于浦肯野神经元倍性的差异进行了讨论，并着重讨论了其基因组部分复制的特例，以及小脑皮质中多倍体浦肯野神经元在小脑叶和疣体中的不同频率。鉴于小脑的区隔结构，本文建议用现代方法和技术对小脑其他区域如小叶进行研究，以确定倍性增加是否与细胞肥大和/或小脑功能刺激有关。
This paper places attention on the discrepancies existing in the literature on the ploidy of Purkinje neurons and focuses on the special case of partial replication of their genome and on the unequal frequency of polyploid Purkinje neurons in the cerebellar cortex of the lobes and the vermis. Owing to the compartmental structure of the cerebellum, this paper suggests the investigation with modern methods and techniques of other cerebellar regions such as the flocculus, with the aim of establishing whether increased ploidy correlates with cell hypertrophy and/or with stimulation of cerebellar functions.