Nickel-Catalyzed Hydrocyanation of Allenes and Its Application.
Nickel-Catalyzed Hydrocyanation of Allenes and Its Application.
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DOI：
10.1248/cpb.c18-00953
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发表时间：
2019-05
影响因子：
1.7
通讯作者：
S. Arai
中科院分区：
文献类型：
--
作者：
S. Arai
氰基 (CN) 相当于羰基以及氨基和羟甲基。因此，它们在金属催化下的催化引入是有机合成化学中的一个重要问题。镍催化氢氰化是研究最深入、最有力的建立 CN 基团的工具之一。然而，控制化学选择性和区域选择性仍然很困难。在这篇综述中，作者使用丙二烯实现了天然产物合成和轴向手性转移的区域、立体和面选择性转化。
Cyano (CN) groups are equivalent to carbonyl as well as amino- and hydroxymethyl groups. Therefore, their catalytic introduction under metal catalysis is an important issue in synthetic organic chemistry. Ni-catalyzed hydrocyanation is one of the most well-investigated, powerful tools for installing a CN group. However, it is still difficult to control chemo- and regioselectivity. In this review, the author uses allenes to enable regio-, stereo-, and face-selective transformations to natural product synthesis and axial chirality transfer.