Evidence That Familial Liability for Psychosis Is Expressed as Differential Sensitivity to Cannabis An Analysis of Patient-Sibling and Sibling-Control Pairs
Evidence That Familial Liability for Psychosis Is Expressed as Differential Sensitivity to Cannabis An Analysis of Patient-Sibling and Sibling-Control Pairs
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DOI：
10.1001/archgenpsychiatry.2010.132
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发表时间：
2011-02-01
影响因子：
--
通讯作者：
Myin-Germeys, Inez
中科院分区：
文献类型：
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作者：
Kahn, Rene S.;Linszen, Don H.;Myin-Germeys, Inez
内容：大麻敏感性的个体差异可能与精神障碍的遗传风险有关。目的：使用2种概念上不同的遗传流行病学设计，（家族）精神病易感性与对大麻的敏感性相关。设计、设置和参与者：同胞对照和交叉同胞比较，使用精神障碍患者（n=1120），其同胞（n=1057），和社区对照组（n=590）在荷兰和弗兰德斯。主要结果测量：积极和消极的精神分裂症结构化访谈修订（为兄弟姐妹和对照组）和自我报告的积极和消极的精神病经验，使用社区评估的精神体验（为兄弟姐妹和患者）。大麻使用被评估为当前使用（通过尿液分析）和终生使用频率（通过复合国际诊断访谈）。结果：在同胞对照比较中，同胞对与尿液分析特别是当前大麻使用相关的阳性血型的敏感性高出15倍以上（校正B=0.197，P
Context: Individual differences in cannabis sensitivity may be associated with genetic risk for psychotic disorder.Objectives: To demonstrate and replicate, using 2 conceptually different genetic epidemiological designs, that (familial) liability to psychosis is associated with sensitivity to cannabis.Design, Setting, and Participants: Sibling-control and cross-sibling comparisons using samples of patients with a psychotic disorder (n=1120), their siblings (n=1057), and community controls (n=590) in the Netherlands and Flanders.Main Outcome Measures: Positive and negative schizotypy using the Structured Interview for Schizotypy-Revised (for siblings and controls) and self-reported positive and negative psychotic experiences using the Community Assessment of Psychic Experiences (for siblings and patients). Cannabis use was assessed as current use (by urinalysis) and lifetime frequency of use (by Composite International Diagnostic Interview).Results: In the sibling-control comparison, siblings displayed more than 15 times greater sensitivity to positive schizotypy associated with particularly current cannabis use by urinalysis (adjusted B=0.197, P