Promiscuous Pseudomonas: Uptake of non-endogenous ligands for iron acquisition
Promiscuous Pseudomonas: Uptake of non-endogenous ligands for iron acquisition
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DOI：
10.1016/j.tetlet.2021.153204
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发表时间：
2021-06-16
影响因子：
1.8
通讯作者：
Wuest, William M.
中科院分区：
文献类型：
--
作者：
Kaplan, Anna R.;Wuest, William M.
铁是几乎所有生物的必需营养素。然而，它的获得对许多生物体构成了重大挑战，包括大多数细菌。细菌吸收铁的主要策略之一是吸收铁载体，铁载体是螯合细胞外铁的小分子。病原性铜绿假单胞菌产生两种不同的铁载体，绿脓菌螯铁蛋白和绿脓菌荧光素。铜绿假单胞菌感测生物可利用的细胞外铁的量，以调节这两种铁载体中的每一种的产生水平。在先前的工作中，我们发现一系列绿脓菌螯铁蛋白生物合成分流产物在铁耗尽条件下与铁预螯合时增强铜绿假单胞菌的生长。因此，在这些结果的基础上，我们研究了一系列非天然氧对应物的这些代谢产物在本研究中的理化和生物学特性。(C)2021爱思唯尔有限公司保留所有权利。
Iron is an essential nutrient to nearly all living beings. However, its acquisition poses a significant challenge to many organisms, including most bacteria. One of the main iron uptake strategies employed by bacteria is the uptake of siderophores, small molecules that chelate extracellular iron. The pathogenic species Pseudomonas aeruginosa produces two different siderophores, pyochelin and pyoverdine. P. aeruginosa senses the amount of bioavailable extracellular iron in order to regulate the production levels of each of these two siderophores. In previous work, we found that a series of pyochelin biosynthetic shunt products enhanced the growth of P. aeruginosa in iron-depleted conditions when prechelated with iron. Thus, on the basis of these results, we investigated the physiochemical and biological properties of a series of non-native oxygen counterparts to these metabolites in the current study. (C) 2021 Elsevier Ltd. All rights reserved.