Layer-by-layer multilayer films linked with reversible boronate ester bonds with glucose-sensitivity under physiological conditions
Layer-by-layer multilayer films linked with reversible boronate ester bonds with glucose-sensitivity under physiological conditions
复制标题
生理条件下具有葡萄糖敏感性的可逆硼酸酯键连接的逐层多层薄膜
DOI：
10.1039/b901910c
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发表时间：
2009-01-01
期刊：
影响因子：
3.4
通讯作者：
Zhu, X. X.
中科院分区：
文献类型：
--
作者：
Ding, Zhibo;Guan, Ying;Zhu, X. X.
Layer-by-layer (LBL) multilayer films were fabricated from poly(vinylalcohol) (PVA) and poly[acrylamide-co-3-(acrylamido)phenylboronic acid] [P(AAm-AAPBA)] by the use of covalent phenylboronate ester bonding as the driving force. The film thickness increases with decreasing pH and increasing ionic strength of the assembly solutions. Phenylboronate ester bonds in the film were confirmed from the IR marker mode at 1730 cm−1. Because the phenylboronate ester bonding is reversible, the PVA/P(AAm-AAPBA) films disassemble gradually when immersed in aqueous solutions. The disassembly rate increases with increasing pH and decreasing ionic strength of the aqueous solutions. Furthermore, the disassembly of the film is accelerated by the addition of glucose, which competes with PVA for phenylboronic acid groups and weakens the interaction between the two polymers. Interestingly, the PVA/P(AAm-AAPBA) film presents glucose-sensitive behavior even under physiological conditions. The enhanced glucose-sensitive behavior at physiological pH may originate from the stabilization of phenylboronate ester by the adjacent amide group. These glucose-sensitive LBL films hold promise for self-regulated insulin release.
