INVESTIGATION OF THE MAGNETIC-PROPERTIES OF IRON-OXIDE NANOPARTICLES USED AS CONTRAST AGENT FOR MRI
INVESTIGATION OF THE MAGNETIC-PROPERTIES OF IRON-OXIDE NANOPARTICLES USED AS CONTRAST AGENT FOR MRI
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DOI：
10.1002/mrm.1910240108
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发表时间：
1992-03-01
影响因子：
3.3
通讯作者：
LEJEUNE, JJ
中科院分区：
文献类型：
--
作者：
POULIQUEN, D;PERROUD, H;LEJEUNE, JJ
超顺磁性氧化铁颗粒是一类新型的MRI造影剂，是非常好的质子弛豫增强剂。然而，这种颗粒系统的发展导致了各种各样的制剂，其物理化学性质差异很大。我们对不同制备的超顺磁性颗粒进行了一系列物理实验：X射线衍射分析、弛豫度测量、磁化率测定和热磁循环。我们的研究结果表明，在室温下和R2/RI比的液体样品中测得的结晶度之间有很好的相关性。液氮温度和室温之间的磁化率测量显示三种不同类型的行为依赖于氧化铁晶体的大小。强场热磁循环的加热和冷却曲线的比较提供了磁赤铁矿/磁铁矿晶体含量的信息。本研究中报告的磁性能信息可能有助于表征和选择这些材料用作MRI造影剂。出版社：Academic Press，Inc.
Superparamagnetic iron oxide particles, a new class of contrast agents for MRI, are extremely good enhancers of proton relaxation. However, the development of such particle systems has resulted in a wide range of preparations whose physico‐chemical properties differ greatly. We have conducted a set of physical experiments: X ray diffraction analysis, relaxivity measurements, susceptibility determinations, and thermomagnetic cycling on different preparations of superparamagnetic particles. Our results demonstrate a good correlation between susceptibilities measured in liquid samples at room temperature and the R2/RI ratio. Susceptibility measurements between liquid nitrogen temperature and room temperature show three different types of behavior dependent on the size of iron oxide crystals. Comparison of heating and cooling curves from strong field thermomagnetic cycles provides information about the maghemite/magnetite crystal content. The information on magnetic properties reported in this study may help to characterize and to select these materials for use as MRI contrast agents. © 1992 Academic Press, Inc.