Women with polycystic ovary syndrome gain regular menstrual cycles when ageing
Women with polycystic ovary syndrome gain regular menstrual cycles when ageing
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DOI：
10.1093/humrep/15.1.24
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发表时间：
2000-01-01
影响因子：
6.1
通讯作者：
Schoemaker, J
中科院分区：
文献类型：
--
作者：
Elting, MW;Korsen, TJM;Schoemaker, J
本研究的目的是调查是否以前少或闭经的多囊卵巢综合征（PCOS）患者在衰老时获得规律的月经周期。根据少尿或闭经和LH浓度增加的组合，登记为PCOS的妇女通过电话接受问卷调查。在这份问卷中，我们询问了普遍的月经周期模式，我们在规则周期（持续短于6周）或不规则周期（长于6周）中进行评分。我们采访了346名30岁及以上的患者，并从分析中排除了141名患者，主要是因为使用口服避孕药。其余205例患者随年龄增长月经周期长度呈高度显著的线性趋势（P < 0.001）。对体重指数、体重减轻、多毛症、既往克罗米芬或促性腺激素治疗、既往妊娠、种族和吸烟进行Logistic回归分析，结果显示年龄对月经周期规律性的影响没有影响。我们得出结论，多囊卵巢新平衡的发展，仅仅是由于卵巢老化过程中卵泡丢失引起的，可以解释老年PCOS患者周期规律的发生。
The aim of this study was to investigate if previously oligo- or amenorrhoeic polycystic ovary syndrome (PCOS) patients gain regular menstrual cycles when ageing. Women registered as having PCOS, based on the combination of oligo- or amenorrhoea and an increased LH concentration, were invited by letter to participate in a questionnaire by telephone. In this questionnaire we asked for the prevalent menstrual cycle pattern, which we scored in regular cycles (persistently shorter than 6 weeks) or irregular cycles (longer than 6 weeks). We interviewed 346 patients of 30 years and older, and excluded 141 from analysis mainly because of the use of oral contraceptives. The remaining 205 patients showed a highly significant linear trend (P < 0.001) for a shorter menstrual cycle length with increasing age. Logistic regression analysis for body mass index, weight loss, hirsutism, previous treatment with clomiphene citrate or gonadotrophins, previous pregnancy, ethnic origin and smoking showed no influence on the effect of age on the regularity of the menstrual cycle, We conclude that the development of a new balance in the polycystic ovary, solely caused by follicle loss through the process of ovarian ageing, can explain the occurrence of regular cycles in older patients with PCOS.